Pavol Jozef Šafárik University in Kosice - Faculty of Medicine

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Research

Research focused on the following research areas:

  • Study of educational methods in order to enhance the quality of anatomy teaching for students from Slovak Republic and students from abroad, which should be made according to recommendations of  European Union experts. Teaching of anatomy for Slovak and foreign students should be coordinated with the use of the same educational approaches for both groups of students. There is an aim to gain good knowledge of anatomy structures of human body with the implementation of their clinical importance in medical practice.
  • Study focused on cancer research in human and experimental animals.  The study concentrates on proteins responsible for multidrug resistance in human cancers (breast, lung, colorectal and renal cancers). In experimental animals is immunohistochemical research of selected protein markers in female rats with chemically induced cancer of the mammary gland.
  • Study the effect of the administration of deprenyl, a MAO-B inhibitor, on the sperm number, sperm DNA fragmentation, the number of pups in the litters, levels of hormones FSH, LH and testosterone in male rats. At the same time is detected of the localization and activity of antioxidant enzymes SODs and CAT in rat testis under physiological and experimental conditions.
  • Study the effect of chronic use of vitamin A on the nervous system of juvenile organism. The functional changes of central nervous system are detected using specific behavioural test, in which are evaluated the basic elements of behaviour, such as locomotor and exploratory activity, physical fitness, emotional behaviour and memory function. Morphological changes are recorded in the structures of limbic system, which are significantly involved in regulation of the behaviour of organisms. Extent of changes is monitored using histological, immunohistochemical and co-localization methods and evaluated by confocal microscope. At the same time is evaluated the extent of oxidative stress, which is determined by grade of damage of DNA circulating lymphocytes and activation of antioxidant enzymes.
  • Study focused on issue of ischemia and ischemic reperfusion injury of the nervous system. On the model of focal cerebral ischemia in rats is monitored the dependence of ischemia and ischemia-reperfusion conditions for the spread of damage to remote anatomically and functionally connected areas of the brain and CNS. At the same time on the basis of these parameters is evaluated the overall system and functional impact on the affected individual.
  • Department of Anatomy collaborate with other departments of Medical Faculty, Faculty of Science UPJŠ, Department of Histology and Embryology Jessenius Faculty of Medicine UK and Institute of Neurobiology SAS

 

Last update: 31.01.2017