{"id":25158,"date":"2017-03-03T11:02:26","date_gmt":"2017-03-03T11:02:26","guid":{"rendered":"https:\/\/www.upjs.sk\/the-research-direction\/"},"modified":"2022-11-09T23:32:03","modified_gmt":"2022-11-09T23:32:03","slug":"the-research-direction","status":"publish","type":"page","link":"https:\/\/www.upjs.sk\/en\/information\/science-and-research\/scientific-and-research-activities-phd-studies\/top-research-teams\/bioactiv\/the-research-direction\/","title":{"rendered":"The research direction"},"content":{"rendered":"

Transcriptome and metabolome of bioactive compounds with anticancer activity in the genus Hypericum <\/em>(guarantee prof. \u010cell\u00e1rov\u00e1)<\/strong><\/p>\n

Research within this topic is concentrated at identification and validation of candidate genes of biosynthesis of bioactive compounds in the genus Hypericum, <\/em>temporal-spatial regulation of their biosynthesis, identification of endophytic microorganisms from the representatives of the genus Hypericum<\/em> and\u00a0characterisation of their biosynthetic potential and at feasibility of targeted enhancement of production of bioactive compounds by biotechnological alternative. \u00a0\u00a0<\/p>\n

Signalome of bioactive compounds with anticancer activity (guarantee prof. Fedoro\u010dko)<\/strong><\/p>\n

This part of research is focused at elucidation of intra- and extracellular signalization during photodynamic cancer therapy because understanding of the processes associated with the cell death, angiogenesis, role of intercellular interactions and the effect of microenvironment, \u00a0autorenewal and differentiation of cancer stem cells, as well as mechanisms of multiple drug resistance may provide, by the knowledge on regulation of the cell signalling pathways, new possibilities for rational therapy and new drugs design.<\/p>\n

Scientometry<\/strong><\/p>\n

The team personalities published together more than 200 original papers which appeared in peer reviewed journals. The number of citations in WOS and Scopus exceeded 4000.<\/p>\n

The most significant papers published in the years 2015-2016<\/strong><\/p>\n

\u00a0\u00a0 \u00a0Spatial chemo-profiling of hypericin and related phytochemicals in Hypericum species using MALDI-HRMS imaging \/ Souvik Kusari … [et al.].
In: Analytical and Bioanalytical Chemistry. – ISSN 1618-2642. – Vol. 407, no. 16 (2015), s. 4779-4791.
[KUSARI, Souvik – SEZGIN, Selahaddin – NIGUTOV\u00c1, Katar\u00edna – \u010cELL\u00c1ROV\u00c1, Eva – SPITELLER, Michael]\u00a0\u00a0\u00a0
\u00a0\u00a0 \u00a0The role of ABA in the freezing injury avoidance in two Hypericum species differing in frost tolerance and potential to synthesize hypericins \/ Katar\u00edna Bru\u0148\u00e1kov\u00e1 … [et al.].
In: Plant Cell Tissue and Organ Culture. – ISSN 0167-6857. – Vol. 122, no. 1 (2015), s. 45-56.
[BRU\u0147\u00c1KOV\u00c1, Katar\u00edna – PETIJOV\u00c1, Linda – Z\u00c1ME\u010cN\u00cdK, Ji\u0159\u00ed – TURE\u010cKOV\u00c1, Veronika – \u010cELL\u00c1ROV\u00c1, Eva]
\u00a0\u00a0 \u00a0Xanthones from roots, hairy roots and cell suspension cultures of selected Hypericum species and their antifungal activity against Candida albicans \/ Daniela Zubrick\u00e1 … [et al.].
In: Plant Cell Reports. – ISSN 0721-7714. – Vol. 34, no. 11 (2015), s. 1953-1962.
[ZUBRICK\u00c1, Daniela – MI\u0160IANIKOV\u00c1, Anna – HENZELYOV\u00c1, Jana – VALLETTA, Alessio – DE ANGELIS, Giulia – DIODATA D\u00b4AURIA, Felicia – SIMONETTI, Giovanna – PASQUA, Gabriella – \u010cELL\u00c1ROV\u00c1, Eva]
\u00a0\u00a0 \u00a0Conservation Strategies in the Genus Hypericum via Cryogenic Treatment \/ Katar\u00edna Bru\u0148\u00e1kov\u00e1, Eva \u010cell\u00e1rov\u00e1.
In: Frontiers in Plant Science. – ISSN 1664-462X. – Vol. 7 (2016), art.no. 558.
[BRU\u0147\u00c1KOV\u00c1, Katar\u00edna – \u010cELL\u00c1ROV\u00c1, Eva]
\u00a0\u00a0 \u00a0Effect of cryoprotectant solution and of cooling rate on crystallization temperature in cryopreserved Hypericum perforatum cell suspension cultures \/ Anna Mi\u0161ianikov\u00e1 … [et al.].
In: Cryoletters. – ISSN 0143-2044. – Vol. 37, no. 3 (2016), s. 173-187.
[MI\u0160IANIKOV\u00c1, Anna – ZUBRICK\u00c1, Daniela – PETIJOV\u00c1, Linda – BRU\u0147\u00c1KOV\u00c1, Katar\u00edna – \u010cELL\u00c1ROV\u00c1, Eva]
\u00a0\u00a0 \u00a0Interspecific variation in localization of hypericins and phloroglucinols in the genus Hypericum as revealed by desorption electrospray ionization mass spectrometry imaging \/ Andrea Kuchar\u00edkov\u00e1 … [et al.].
In: Physiologia Plantarum. – ISSN 0031-9317. – Vol. 157, no. 1 (2016), s. 2-12.
[KUCHAR\u00cdKOV\u00c1, Andrea – KIM\u00c1KOV\u00c1, Katar\u00edna – JANFLET, Christian – \u010cELL\u00c1ROV\u00c1, Eva]
\u00a0\u00a0\u00a0 Occurrence and distribution of phytochemicals in the leaves of 17 in vitro cultured Hypericum spp. adapted to outdoor conditions \/ Andrea Kuchar\u00edkov\u00e1 … [et al.]. In: Frontiers in Plant Science. – ISSN 1664-462X. – Vol. 7 (2016), art.no. 1616.
[KUCHAR\u00cdKOV\u00c1, Andrea – KUSARI, Souvik – SEZGIN, Selahaddin – SPITELLER, Michael – \u010cELL\u00c1ROV\u00c1, Eva]
\u00a0\u00a0\u00a0 Differentially Expressed Genes in Hypericin-Containing Hypericum perforatum Leaf Tissues as Revealed by De Novo Assembly of RNA-Seq \/Miroslav Sot\u00e1k … [et al.]. In Plant Molecular Biology Reporter. – ISSN: 0735-9640 \u2013 Vol. 34 (2016), number 5, s. 1027-1041
[SOT\u00c1K, Miroslav \u2013 CZERANKOV\u00c1, Odeta \u2013 KLEIN, Daniel \u2013 NIGUTOV\u00c1, Katar\u00edna –\u00a0 ALTSCHMIED, Lothar, LI, Ling \u2013 JOSE, Adarsh \u2013 WURTELE, Eva Syrkin – \u010cELL\u00c1ROV\u00c1, Eva]
\u00a0\u00a0\u00a0 Comparative transcriptome reconstruction of four Hypericum species focused on hypericin biosynthesis \/ Miroslav Sot\u00e1k … [et al.]. In: Frontiers in Plant Science. – ISSN 1664-462X. – Vol. 7 (2016), art.no. 1039
[SOT\u00c1K, Miroslav \u2013 CZERANKOV\u00c1, Odeta \u2013 KLEIN, Daniel \u2013 JUR\u010cACKOV\u00c1, Zuzana –\u00a0 LI, Ling \u2013 \u010cELL\u00c1ROV\u00c1, Eva]
\u00a0\u00a0\u00a0 Shoot tip meristem cryopreservation of Hypericum Species \/ Katar\u00edna Bru\u0148\u00e1kov\u00e1, Eva \u010cell\u00e1rov\u00e1. In: Protocols for In Vitro Cultures and Secondary Metabolite Analysis of Aromatic and Medicinal Plants. – Nev York : Springer Science+Business Media, 2016. – ISBN 9781493933303. – S. 31-46
\u00a0\u00a0\u00a0 DNA-protective activities of hyperforin and aristoforin \/ A. \u0160ev\u010dovi\u010dov\u00e1 … [et al.].
In: Toxicology in Vitro. – ISSN 0887-2333. – Vol. 29, no. 3 (2015), s. 631-637.
[\u0160EV\u010cOVI\u010cOV\u00c1, Andrea – \u0160EMEL\u00c1KOV\u00c1, Martina – PL\u0160\u00cdKOV\u00c1, Jana – LODERER, Du\u0161an – IMREOV\u00c1, Petronela – G\u00c1LOV\u00c1, Eli\u0161ka – KO\u017dURKOV\u00c1, M\u00e1ria – MIADOKOV\u00c1, Eva – FEDORO\u010cKO, Peter]
\u00a0\u00a0\u00a0 Downregulation of BCRP and anti-apoptotic proteins by proadifen (SKF-525A) is responsible for enhanced mitoxantrone accumulation and toxicity in mitoxantrone-resistant human promyelocytic leukemia cells \/ Lucia Hi\u013eovsk\u00e1 … [et al.].
In: International Journal of Oncology. – ISSN 1019-6439. – Vol. 47, no. 4 (2015), s. 1572-1584.
[HI\u013dOVSK\u00c1, Lucia – JEND\u017dELOVSK\u00dd, Rastislav – JEND\u017dELOVSK\u00c1, Zuzana – KOVA\u013d, J\u00e1n – FEDORO\u010cKO, Peter]
\u00a0\u00a0\u00a0 Potentiation of hypericin-mediated photodynamic therapy cytotoxicity by MK-886: Focus on ABC transporters, GDF-15 and redox status \/ Barbora Kuch\u00e1rov\u00e1 … [et al.].
In: Photodiagnosis and Photodynamic Therapy. – ISSN 1572-1000. – Vol. 12, no. 3 (2015), s. 490-503.
[KUCH\u00c1ROV\u00c1, Barbora – MIKE\u0160, Jarom\u00edr – JEND\u017dELOVSK\u00dd, Rastislav – VARGOV\u00c1, Jana – MIKE\u0160OV\u00c1, Lucia – JEND\u017dELOVSK\u00c1, Zuzana – KOVA\u013d, J\u00e1n – FEDORO\u010cKO, Peter]
\u00a0\u00a0\u00a0 Drug membrane transporters and CYP3A4 are affected by hypericin, hyperforin or aristoforin in colon adenocarcinoma cells \/ M. \u0160emel\u00e1kov\u00e1, R. Jend\u017eelovsk\u00fd, P. Fedoro\u010dko.
In: Biomedicine & Pharmacotherapy. – ISSN 0753-3322. – Vol. 81 (2016), s. 38-47.
[\u0160EMEL\u00c1KOV\u00c1, Martina – JEND\u017dELOVSK\u00dd, Rastislav – FEDORO\u010cKO, Peter]
\u00a0\u00a0\u00a0 Hypericin in the light and in the dark: two sides of the same coin \/ Zuzana Jend\u017eelovsk\u00e1 … [et al.].
In: Frontiers in Plant Science. – ISSN 1664-462X. – Vol. 7 (2016), art.no. 560.
[JEND\u017dELOVSK\u00c1, Zuzana – JEND\u017dELOVSK\u00dd, Rastislav – KUCH\u00c1ROV\u00c1, Barbora – FEDORO\u010cKO, Peter]
\u00a0\u00a0\u00a0 Proadifen sensitizes resistant ovarian adenocarcinoma cells to cisplatin \/ Rastislav Jend\u017eelovsk\u00fd … [et al.].
In: Toxicology Letters. – ISSN 0378-4274. – Vol. 243 (2016), s. 56-66.
[JEND\u017dELOVSK\u00dd, Rastislav – JEND\u017dELOVSK\u00c1, Zuzana – HI\u013dOVSK\u00c1, Lucia – KOVA\u013d, J\u00e1n – MIKE\u0160, Jarom\u00edr – FEDORO\u010cKO, Peter]
\u00a0\u00a0\u00a0 YM155, a small molecule inhibitor of survivin expression, sensitizes cancer cells to hypericin-mediated photodynamic therapy \/ Katar\u00edna Gyuraszova … [et al.].
In: Photochemical & Photobiological Sciences. – ISSN 1474-905X. – Vol. 15, no. 6 (2016), s. 812-821.
[GYUR\u00c1SZOV\u00c1, Katar\u00edna – MIKE\u0160, Jarom\u00edr – HALABURKOV\u00c1, Andrea – JEND\u017dELOVSK\u00dd, Rastislav – FEDORO\u010cKO, Peter]<\/p>\n","protected":false},"excerpt":{"rendered":"

Transcriptome and metabolome of bioactive compounds with anticancer activity in the genus Hypericum (guarantee prof. \u010cell\u00e1rov\u00e1) Research within this topic is concentrated at identification and validation of candidate genes of biosynthesis of bioactive compounds in the genus Hypericum, temporal-spatial regulation of their biosynthesis, identification of endophytic microorganisms from the representatives of the genus Hypericum and\u00a0characterisation … Continued<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":25073,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","footnotes":""},"categories":[],"tags":[],"class_list":["post-25158","page","type-page","status-publish","hentry"],"acf":{"acf_link_na_externy_obsah":""},"yoast_head":"\nThe research direction - UPJ\u0160 Ko\u0161ice<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.upjs.sk\/en\/information\/science-and-research\/scientific-and-research-activities-phd-studies\/top-research-teams\/bioactiv\/the-research-direction\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The research direction - UPJ\u0160 Ko\u0161ice\" \/>\n<meta property=\"og:description\" content=\"Transcriptome and metabolome of bioactive compounds with anticancer activity in the genus Hypericum (guarantee prof. \u010cell\u00e1rov\u00e1) Research within this topic is concentrated at identification and validation of candidate genes of biosynthesis of bioactive compounds in the genus Hypericum, temporal-spatial regulation of their biosynthesis, identification of endophytic microorganisms from the representatives of the genus Hypericum and\u00a0characterisation … Continued\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.upjs.sk\/en\/information\/science-and-research\/scientific-and-research-activities-phd-studies\/top-research-teams\/bioactiv\/the-research-direction\/\" \/>\n<meta property=\"og:site_name\" content=\"UPJ\u0160 Ko\u0161ice\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/UniverzitaPavlaJozefaSafarikaVkosiciach\/\" \/>\n<meta property=\"article:modified_time\" content=\"2022-11-09T23:32:03+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@UPJS_kosice\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.upjs.sk\\\/en\\\/information\\\/science-and-research\\\/scientific-and-research-activities-phd-studies\\\/top-research-teams\\\/bioactiv\\\/the-research-direction\\\/\",\"url\":\"https:\\\/\\\/www.upjs.sk\\\/en\\\/information\\\/science-and-research\\\/scientific-and-research-activities-phd-studies\\\/top-research-teams\\\/bioactiv\\\/the-research-direction\\\/\",\"name\":\"The research direction - UPJ\u0160 Ko\u0161ice\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.upjs.sk\\\/en\\\/#website\"},\"datePublished\":\"2017-03-03T11:02:26+00:00\",\"dateModified\":\"2022-11-09T23:32:03+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.upjs.sk\\\/en\\\/information\\\/science-and-research\\\/scientific-and-research-activities-phd-studies\\\/top-research-teams\\\/bioactiv\\\/the-research-direction\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.upjs.sk\\\/en\\\/information\\\/science-and-research\\\/scientific-and-research-activities-phd-studies\\\/top-research-teams\\\/bioactiv\\\/the-research-direction\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.upjs.sk\\\/en\\\/information\\\/science-and-research\\\/scientific-and-research-activities-phd-studies\\\/top-research-teams\\\/bioactiv\\\/the-research-direction\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.upjs.sk\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Information\",\"item\":\"https:\\\/\\\/www.upjs.sk\\\/en\\\/information\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Science, Research and Development\",\"item\":\"https:\\\/\\\/www.upjs.sk\\\/en\\\/information\\\/science-and-research\\\/\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Scientific and Research Activities, PhD Studies\",\"item\":\"https:\\\/\\\/www.upjs.sk\\\/en\\\/information\\\/science-and-research\\\/scientific-and-research-activities-phd-studies\\\/\"},{\"@type\":\"ListItem\",\"position\":5,\"name\":\"Top Research Teams\",\"item\":\"https:\\\/\\\/www.upjs.sk\\\/en\\\/information\\\/science-and-research\\\/scientific-and-research-activities-phd-studies\\\/top-research-teams\\\/\"},{\"@type\":\"ListItem\",\"position\":6,\"name\":\"The Research Team of Bioactive Substances for Biomedical Applications (BIOACTIV)\",\"item\":\"https:\\\/\\\/www.upjs.sk\\\/en\\\/information\\\/science-and-research\\\/scientific-and-research-activities-phd-studies\\\/top-research-teams\\\/bioactiv\\\/\"},{\"@type\":\"ListItem\",\"position\":7,\"name\":\"The research direction\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.upjs.sk\\\/en\\\/#website\",\"url\":\"https:\\\/\\\/www.upjs.sk\\\/en\\\/\",\"name\":\"UPJ\u0160 Ko\u0161ice\",\"description\":\"Wisdom of the Past, Knowledge of the Present, Education of the Future\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.upjs.sk\\\/en\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.upjs.sk\\\/en\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.upjs.sk\\\/en\\\/#organization\",\"name\":\"UPJ\u0160 Ko\u0161ice\",\"url\":\"https:\\\/\\\/www.upjs.sk\\\/en\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.upjs.sk\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.upjs.sk\\\/app\\\/uploads\\\/2023\\\/01\\\/UPJS_ENG_esymbol.svg\",\"contentUrl\":\"https:\\\/\\\/www.upjs.sk\\\/app\\\/uploads\\\/2023\\\/01\\\/UPJS_ENG_esymbol.svg\",\"width\":448,\"height\":139,\"caption\":\"UPJ\u0160 Ko\u0161ice\"},\"image\":{\"@id\":\"https:\\\/\\\/www.upjs.sk\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/UniverzitaPavlaJozefaSafarikaVkosiciach\\\/\",\"https:\\\/\\\/x.com\\\/UPJS_kosice\",\"https:\\\/\\\/www.instagram.com\\\/upjs_kosice\",\"https:\\\/\\\/www.linkedin.com\\\/company\\\/pavol-jozef-afrik-university-in-koice\\\/\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"The research direction - UPJ\u0160 Ko\u0161ice","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.upjs.sk\/en\/information\/science-and-research\/scientific-and-research-activities-phd-studies\/top-research-teams\/bioactiv\/the-research-direction\/","og_locale":"en_US","og_type":"article","og_title":"The research direction - UPJ\u0160 Ko\u0161ice","og_description":"Transcriptome and metabolome of bioactive compounds with anticancer activity in the genus Hypericum (guarantee prof. \u010cell\u00e1rov\u00e1) Research within this topic is concentrated at identification and validation of candidate genes of biosynthesis of bioactive compounds in the genus Hypericum, temporal-spatial regulation of their biosynthesis, identification of endophytic microorganisms from the representatives of the genus Hypericum and\u00a0characterisation … Continued","og_url":"https:\/\/www.upjs.sk\/en\/information\/science-and-research\/scientific-and-research-activities-phd-studies\/top-research-teams\/bioactiv\/the-research-direction\/","og_site_name":"UPJ\u0160 Ko\u0161ice","article_publisher":"https:\/\/www.facebook.com\/UniverzitaPavlaJozefaSafarikaVkosiciach\/","article_modified_time":"2022-11-09T23:32:03+00:00","twitter_card":"summary_large_image","twitter_site":"@UPJS_kosice","twitter_misc":{"Est. reading time":"5 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.upjs.sk\/en\/information\/science-and-research\/scientific-and-research-activities-phd-studies\/top-research-teams\/bioactiv\/the-research-direction\/","url":"https:\/\/www.upjs.sk\/en\/information\/science-and-research\/scientific-and-research-activities-phd-studies\/top-research-teams\/bioactiv\/the-research-direction\/","name":"The research direction - UPJ\u0160 Ko\u0161ice","isPartOf":{"@id":"https:\/\/www.upjs.sk\/en\/#website"},"datePublished":"2017-03-03T11:02:26+00:00","dateModified":"2022-11-09T23:32:03+00:00","breadcrumb":{"@id":"https:\/\/www.upjs.sk\/en\/information\/science-and-research\/scientific-and-research-activities-phd-studies\/top-research-teams\/bioactiv\/the-research-direction\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.upjs.sk\/en\/information\/science-and-research\/scientific-and-research-activities-phd-studies\/top-research-teams\/bioactiv\/the-research-direction\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.upjs.sk\/en\/information\/science-and-research\/scientific-and-research-activities-phd-studies\/top-research-teams\/bioactiv\/the-research-direction\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.upjs.sk\/en\/"},{"@type":"ListItem","position":2,"name":"Information","item":"https:\/\/www.upjs.sk\/en\/information\/"},{"@type":"ListItem","position":3,"name":"Science, Research and Development","item":"https:\/\/www.upjs.sk\/en\/information\/science-and-research\/"},{"@type":"ListItem","position":4,"name":"Scientific and Research Activities, PhD Studies","item":"https:\/\/www.upjs.sk\/en\/information\/science-and-research\/scientific-and-research-activities-phd-studies\/"},{"@type":"ListItem","position":5,"name":"Top Research Teams","item":"https:\/\/www.upjs.sk\/en\/information\/science-and-research\/scientific-and-research-activities-phd-studies\/top-research-teams\/"},{"@type":"ListItem","position":6,"name":"The Research Team of Bioactive Substances for Biomedical Applications (BIOACTIV)","item":"https:\/\/www.upjs.sk\/en\/information\/science-and-research\/scientific-and-research-activities-phd-studies\/top-research-teams\/bioactiv\/"},{"@type":"ListItem","position":7,"name":"The research direction"}]},{"@type":"WebSite","@id":"https:\/\/www.upjs.sk\/en\/#website","url":"https:\/\/www.upjs.sk\/en\/","name":"UPJ\u0160 Ko\u0161ice","description":"Wisdom of the Past, Knowledge of the Present, Education of the Future","publisher":{"@id":"https:\/\/www.upjs.sk\/en\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.upjs.sk\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.upjs.sk\/en\/#organization","name":"UPJ\u0160 Ko\u0161ice","url":"https:\/\/www.upjs.sk\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.upjs.sk\/en\/#\/schema\/logo\/image\/","url":"https:\/\/www.upjs.sk\/app\/uploads\/2023\/01\/UPJS_ENG_esymbol.svg","contentUrl":"https:\/\/www.upjs.sk\/app\/uploads\/2023\/01\/UPJS_ENG_esymbol.svg","width":448,"height":139,"caption":"UPJ\u0160 Ko\u0161ice"},"image":{"@id":"https:\/\/www.upjs.sk\/en\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/UniverzitaPavlaJozefaSafarikaVkosiciach\/","https:\/\/x.com\/UPJS_kosice","https:\/\/www.instagram.com\/upjs_kosice","https:\/\/www.linkedin.com\/company\/pavol-jozef-afrik-university-in-koice\/"]}]}},"_links":{"self":[{"href":"https:\/\/www.upjs.sk\/en\/wp-json\/wp\/v2\/pages\/25158","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.upjs.sk\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.upjs.sk\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.upjs.sk\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.upjs.sk\/en\/wp-json\/wp\/v2\/comments?post=25158"}],"version-history":[{"count":2,"href":"https:\/\/www.upjs.sk\/en\/wp-json\/wp\/v2\/pages\/25158\/revisions"}],"predecessor-version":[{"id":41641,"href":"https:\/\/www.upjs.sk\/en\/wp-json\/wp\/v2\/pages\/25158\/revisions\/41641"}],"up":[{"embeddable":true,"href":"https:\/\/www.upjs.sk\/en\/wp-json\/wp\/v2\/pages\/25073"}],"wp:attachment":[{"href":"https:\/\/www.upjs.sk\/en\/wp-json\/wp\/v2\/media?parent=25158"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.upjs.sk\/en\/wp-json\/wp\/v2\/categories?post=25158"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.upjs.sk\/en\/wp-json\/wp\/v2\/tags?post=25158"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}