{"id":31855,"date":"2021-06-11T13:34:43","date_gmt":"2021-06-11T13:34:43","guid":{"rendered":"https:\/\/www.upjs.sk\/lekarska-fakulta\/klinika\/root\/urologia\/vyskum\/"},"modified":"2022-11-13T22:12:08","modified_gmt":"2022-11-13T21:12:08","slug":"vyskum","status":"publish","type":"cpt_klinika","link":"https:\/\/www.upjs.sk\/lekarska-fakulta\/klinika\/urologia\/vyskum\/","title":{"rendered":"Vedecko-v\u00fdskumn\u00e1 \u010dinnos\u0165 kliniky"},"content":{"rendered":"<p><strong>V\u00fdskumn\u00e9 zameranie pracoviska:<\/strong><\/p>\n<p style=\"text-align:justify; text-indent:2em\">Urologick\u00e1 klinika LF UPJ\u0160 ako klinick\u00fd odbor nedisponuje vlastn\u00fdmi v\u00fdskumn\u00fdmi laborat\u00f3riami. Vedecko-v\u00fdskumn\u00e1 \u010dinnos\u0165 je zameran\u00e1 predov\u0161etk\u00fdm na spolupr\u00e1cu s predklinick\u00fdmi odbormi a \u00fastavmi. Urologick\u00e1 klinika spolupracuje na rie\u0161en\u00ed vedecko-v\u00fdskumnej \u00falohy s \u00dastavom lek\u00e1rskej a klinickej bioch\u00e9mie od za\u010diatku roku 2016. Prof. MUDr. Vincent Nagy, PhD. MPH je z\u00e1stupcom ved\u00faceho projektu VEGA grantu registra\u010dn\u00e9 \u010d\u00edslo 1\/0372\/17 (ved\u00facou je prof. Ing. M. Marekov\u00e1, CSc.).<br \/>\nN\u00e1zov projektu:<\/p>\n<p style=\"text-align:justify; text-indent:2em\"><strong>\u201eVyu\u017eitie miRNA a fluorescen\u010dn\u00fdch techn\u00edk v diagnostike n\u00e1dorov mo\u010dov\u00e9ho mech\u00fara\u201c.<\/strong><\/p>\n<p style=\"text-align:justify; text-indent:2em\">\u010eal\u0161ou pl\u00e1novanou v\u00fdskumnou aktivitou je zapojenie sa do projektu klinickej \u0161t\u00fadie BL006 s n\u00e1zvom:<\/p>\n<p style=\"text-align:justify; text-indent:2em\"><strong>\u201eRandomizovan\u00e9, kontrolovan\u00e9, otvoren\u00e9 klinick\u00e9 sk\u00fa\u0161anie na zhodnotenie \u00fa\u010dinnosti, v\u00fddr\u017ee a bezpe\u010dnosti sk\u00fa\u0161an\u00e9ho lieku UGN-102 v kombin\u00e1cii s TURBT (transuretr\u00e1lnou resekciou tumoru mo\u010dov\u00e9ho mech\u00fara) alebo bez nej u pacientov s n\u00edzkym stup\u0148om stredn\u00e9ho rizika svalovinu neinfiltruj\u00facej rakoviny mo\u010dov\u00e9ho mech\u00fara (LG IR-NMIBC) (ATLAS).\u201c<\/strong><br \/>\n<span style=\"margin-left:2em\">Prim\u00e1rnym cie\u013eom klinickej \u0161t\u00fadie BL006 je DFS Diease free survival, pre\u017e\u00edvanie pacienta bez ochorenia po\u010das trvania \u0161t\u00fadie (maxim\u00e1lne 24 mesiacov).<br \/>\n<span style=\"margin-left:2em\">Sekund\u00e1rnymi cie\u013emi s\u00fa:<br \/>\n&#8211; \u010das do rekurencie, TTR, \u010das od randomiz\u00e1cie do zdokumentovania prvej rekurencie ochorenia,<br \/>\n&#8211; pomer kompletnej odpovede CRR, definovan\u00e1 ako proporcia pacientov ktor\u00ed dosiahnu kompletn\u00fa odpove\u010f pri 3 mesa\u010dnom vyhodnoten\u00ed,<br \/>\n&#8211; trvanie odpovede DOR, definovan\u00fd ako \u010das od zdokumentovanej prvej kompletnej odpovede po zdokumentovan\u00fa prv\u00fa rekurenciu ochorenia alebo smr\u0165 u pacientov ktor\u00ed dosiahli CR pri 3 mesa\u010dnom vyhodnoten\u00ed,<br \/>\n&#8211; proporcia pacientov ktor\u00ed dosiahnu kompletn\u00fa odpove\u010f pri 3 mesa\u010dnom vyhodnoten\u00ed a udr\u017eia si ju do konkr\u00e9tneho vyhodnotenia,<br \/>\n&#8211; incidencia TURBT \u2013 proporcia pacientov ktor\u00ed bud\u00fa vy\u017eadova\u0165 TURBT v ka\u017edom ramene a priemern\u00fd po\u010det TURBT na pacienta v ka\u017edom ramene<br \/>\n&#8211; zmeny v dotazn\u00edku kvality HRQoL<br \/>\n<span style=\"margin-left:2em\">Non-responder je pacient, ktor\u00fd v r\u00e1mci \u0161t\u00fadie BL006 bude vyhodnoten\u00fd ako pacient ktor\u00fd nedosiahol Kompletn\u00fa odpove\u010f v 3. mesiaci vyhodnotenia a po tomto obdob\u00ed. Pokia\u013e je tumor pri 3 mesa\u010dnej vizite vidite\u013en\u00fd, l\u00e9zie sa podrobia biopsii a pokia\u013e histopatol\u00f3gia potvrd\u00ed rakovinu, pacient bude vyhodnoten\u00fd ako NCR (noncomplete responder).<br \/>\n<span style=\"margin-left:2em\">In\u00e9 potenci\u00e1lne ciele klinick\u00e9ho sk\u00fa\u0161ania m\u00f4\u017eu by\u0165 zahrnut\u00e9 v \u010fal\u0161\u00edch bud\u00facich klinick\u00fdch \u0161t\u00fadi\u00e1ch.<\/span><\/span><\/span><\/span><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":31835,"menu_order":3,"template":"","meta":{"_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","footnotes":""},"categories":[],"tags":[],"tax_aktuality":[],"acf":{"acf_link_na_externy_obsah":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Vedecko-v\u00fdskumn\u00e1 \u010dinnos\u0165 kliniky - Lek\u00e1rska fakulta | UPJ\u0160<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.upjs.sk\/lekarska-fakulta\/klinika\/urologia\/vyskum\/\" \/>\n<meta property=\"og:locale\" content=\"sk_SK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Vedecko-v\u00fdskumn\u00e1 \u010dinnos\u0165 kliniky - Lek\u00e1rska fakulta | UPJ\u0160\" \/>\n<meta property=\"og:description\" content=\"V\u00fdskumn\u00e9 zameranie pracoviska: Urologick\u00e1 klinika LF UPJ\u0160 ako klinick\u00fd odbor nedisponuje vlastn\u00fdmi v\u00fdskumn\u00fdmi laborat\u00f3riami. 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