{"id":29348,"date":"2022-04-04T15:44:26","date_gmt":"2022-04-04T15:44:26","guid":{"rendered":"https:\/\/www.upjs.sk\/lekarska-fakulta\/ustav\/root\/lekarska-a-klinicka-biofyzika\/vyskum\/"},"modified":"2023-07-07T10:40:12","modified_gmt":"2023-07-07T09:40:12","slug":"vyskum","status":"publish","type":"cpt_ustav","link":"https:\/\/www.upjs.sk\/lekarska-fakulta\/ustav\/lekarska-a-klinicka-biofyzika\/vyskum\/","title":{"rendered":"Vedecko-v\u00fdskumn\u00e1 \u010dinnos\u0165 \u00fastavu"},"content":{"rendered":"

V\u00fdskum na oddelen\u00ed lek\u00e1rskej a klinickej biofyziky je zameran\u00fd na sledovanie proteomick\u00fdch zmien klinick\u00fdch vzoriek ako aj bunkov\u00fdch l\u00edni\u00ed s vyu\u017eit\u00edm hmotnostnej spektrometrie. Laborat\u00f3rium je zameran\u00e9 na tzv. shotgun anal\u00fdzu s vyu\u017eit\u00edm identifik\u00e1cie prote\u00ednov pr\u00edstupom zdola nahor (pomocou identifik\u00e1cie peptidov z\u00edskan\u00fdch digesciou prote\u00ednov vhodn\u00fdm enz\u00fdmom, zvy\u010dajne tryps\u00ednom, tzv. bottom-up anal\u00fdzy). Oddelenie disponuje technikou, ktorou dok\u00e1\u017ee tie\u017e analyzova\u0165 aj intaktn\u00e9 prote\u00edny – cel\u00e9 molekuly bielkov\u00edn pomocou tzv. top-down anal\u00fdzy, zhora nadol. Na separ\u00e1ciu peptidu \/ prote\u00ednu sa pou\u017e\u00edvaj\u00fa r\u00f4zne met\u00f3dy vyu\u017e\u00edvaj\u00face jednorozmern\u00fa alebo dvojrozmern\u00fa g\u00e9lov\u00fa elektrofor\u00e9zu, frakcion\u00e1ciu mimo g\u00e9lu alebo viacrozmern\u00fa HPLC. Laborat\u00f3rium sa tie\u017e venuje \u0161t\u00fadiu vplyvu neioniza\u010dn\u00fdch elektromagnetick\u00fdch pol\u00ed na fyziologick\u00e9 a biochemick\u00e9 procesy v bunk\u00e1ch ako aj na zmenu ich prote\u00f3mu. Nako\u013eko enz\u00fdmy a ostatn\u00e9 molekuly maj\u00fa vlastn\u00fd magnetick\u00fd moment rovnako ako aj molekuly lie\u010div, vyn\u00e1ra sa zauj\u00edmav\u00e1 mo\u017enos\u0165 sk\u00famania ovplyv\u0148ovania terapie magnetick\u00fdmi po\u013eami pomocou kon\u0161truovan\u00e9ho zariadenia. Na laborat\u00f3rne l\u00ednie hum\u00e1nnych n\u00e1dorov\u00fdch buniek, chondrocyty a bakt\u00e9rie s\u00fa aplikovan\u00e9 neioniza\u010dn\u00e9 elektromagnetick\u00e9 polia v kombin\u00e1cii s cytostatikami a \u010fal\u0161\u00edmi biologicky akt\u00edvnymi molekulami. V s\u00fa\u010dasnosti sa v\u00fdskum na \u00fastave venuje nasledovn\u00fdm t\u00e9mam:<\/p>\n

    \n
  1. \u0160t\u00fadium zmien v prote\u00f3me buniek v s\u00favislosti s r\u00f4znymi ochoreniami za pomoci elektroforetickej separ\u00e1cie prote\u00ednov a chromatografickej separ\u00e1cie peptidov nasledovanej identifik\u00e1ciou s vyu\u017eit\u00edm hmotnostnej spektrometrie s r\u00f4znymi typmi hmotnostn\u00fdch analyz\u00e1torov (MALDI-TOF\/TOF – matricou asistovan\u00e1 laserov\u00e1 desorpcia\/ioniz\u00e1cia s analyz\u00e1torom doby letu, Q\/TOF – tandemov\u00e9 spojenie analyz\u00e1torov kvadrup\u00f3l a analyz\u00e1tor doby letu, IT – i\u00f3nov\u00e1 pasca, QQQ – trojit\u00fd kvadrup\u00f3l) za \u00fa\u010delom vyselektovania vhodn\u00fdch prote\u00ednov\u00fdch biomarkerov, ako aj sledovania \u00fa\u010dinnosti terapeutick\u00fdch postupov v personalizovanej medic\u00edne.
    \nPredmetom proteomick\u00e9ho \u0161t\u00fadia s\u00fa<\/p>\n
      \n
    1. zmeny prote\u00f3mu laborat\u00f3rnych l\u00edni\u00ed hum\u00e1nnych n\u00e1dorov\u00fdch buniek (l\u00ednia buniek karcin\u00f3mu prsn\u00edka MCF7) po vystaven\u00ed r\u00f4znym terapeutick\u00fdm podmienkam<\/li>\n
    2. zmeny prote\u00f3mu leukocytov u pacientov s onkologick\u00fdmi ochoreniami a ako aj ochoren\u00edm na COVID-19<\/li>\n
    3. zmeny prote\u00f3mu prote\u00ednov v mo\u010di v s\u00favislosti s artrotick\u00fdmi zmenami k\u013abov<\/li>\n
    4. zmeny prote\u00f3mu krvn\u00fdch do\u0161ti\u010diek a mozgovo-mie\u0161neho moku u suicid\u00e1lnych pacientov<\/li>\n
    5. zmeny prote\u00f3mu sl\u00edn vo vz\u0165ahu k chorob\u00e1m v \u00fastnej dutine.
      \n\t\t <\/li>\n<\/ol>\n<\/li>\n
    6. \u0160t\u00fadium interakcie medic\u00ednsky relevantn\u00fdch molek\u00fal s lipidov\u00fdmi modelov\u00fdmi membr\u00e1nami. V laborat\u00f3ri\u00e1ch \u00fastavu je vyv\u00edjan\u00e1 met\u00f3da formovania lipidov\u00fdch membr\u00e1n na tuhom povrchu, ktor\u00e9 predstavuj\u00fa model plazmatickej bunkovej membr\u00e1ny.
      \n\t <\/li>\n
    7. \u0160t\u00fadium biostimul\u00e1cie hojenia r\u00e1n laserov\u00fdm \u017eiaren\u00edm na molekulovej, bunkovej a tkanivovej \u00farovni.<\/li>\n<\/ol>\n","protected":false},"author":1,"featured_media":0,"parent":29325,"menu_order":3,"template":"","meta":{"_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","footnotes":""},"categories":[],"tags":[],"tax_aktuality":[],"acf":{"acf_link_na_externy_obsah":""},"yoast_head":"\nVedecko-v\u00fdskumn\u00e1 \u010dinnos\u0165 \u00fastavu - Lek\u00e1rska fakulta | UPJ\u0160<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.upjs.sk\/lekarska-fakulta\/ustav\/lekarska-a-klinicka-biofyzika\/vyskum\/\" \/>\n<meta property=\"og:locale\" content=\"sk_SK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Vedecko-v\u00fdskumn\u00e1 \u010dinnos\u0165 \u00fastavu - Lek\u00e1rska fakulta | UPJ\u0160\" \/>\n<meta property=\"og:description\" content=\"V\u00fdskum na oddelen\u00ed lek\u00e1rskej a klinickej biofyziky je zameran\u00fd na sledovanie proteomick\u00fdch zmien klinick\u00fdch vzoriek ako aj bunkov\u00fdch l\u00edni\u00ed s vyu\u017eit\u00edm hmotnostnej spektrometrie. 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