{"id":14356,"date":"2021-01-11T15:35:56","date_gmt":"2021-01-11T15:35:56","guid":{"rendered":"https:\/\/www.upjs.sk\/pracoviska\/tip\/sp\/"},"modified":"2025-09-28T21:44:40","modified_gmt":"2025-09-28T21:44:40","slug":"sp","status":"publish","type":"page","link":"https:\/\/www.upjs.sk\/pracoviska\/tip\/en\/sp\/","title":{"rendered":"Significant Projects"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-cierna-color\">PROJECTS SUPPORTED BY THE RECOVERY AND RESILIENCE PLAN<\/mark><\/h2>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Project APBC<\/h2>\n\n\n\n<p><\/p>\n\n\n<style>.kb-row-layout-id14356_20e863-71 > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id14356_20e863-71 > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id14356_20e863-71 > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-sm, 1.5rem);grid-template-columns:repeat(2, minmax(0, 1fr));}.kb-row-layout-id14356_20e863-71 > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id14356_20e863-71 > .kt-row-column-wrap{grid-template-columns:repeat(2, minmax(0, 1fr));}}@media all and (max-width: 767px){.kb-row-layout-id14356_20e863-71 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id14356_20e863-71 alignnone wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-2-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top\">\n<style>.kadence-column14356_65089f-44 > .kt-inside-inner-col,.kadence-column14356_65089f-44 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column14356_65089f-44 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column14356_65089f-44 > .kt-inside-inner-col{flex-direction:column;}.kadence-column14356_65089f-44 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column14356_65089f-44 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column14356_65089f-44{position:relative;}@media all and (max-width: 1024px){.kadence-column14356_65089f-44 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column14356_65089f-44 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column14356_65089f-44\"><div class=\"kt-inside-inner-col\">\n<figure class=\"wp-block-image size-full is-resized\"><a href=\"https:\/\/www.upjs.sk\/pracoviska\/tip\/en\/apbc\/\"><img loading=\"lazy\" decoding=\"async\" width=\"4918\" height=\"2112\" src=\"https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/06\/color_transparent_APBC.png\" alt=\"\" class=\"wp-image-18811\" style=\"width:286px;height:auto\" srcset=\"https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/06\/color_transparent_APBC.png 4918w, https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/06\/color_transparent_APBC-300x129.png 300w, https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/06\/color_transparent_APBC-1024x440.png 1024w, https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/06\/color_transparent_APBC-768x330.png 768w, https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/06\/color_transparent_APBC-1536x660.png 1536w, https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/06\/color_transparent_APBC-2048x879.png 2048w\" sizes=\"auto, (max-width: 4918px) 100vw, 4918px\" \/><\/a><\/figure>\n<\/div><\/div>\n\n\n<style>.kadence-column14356_ca0659-03 > .kt-inside-inner-col,.kadence-column14356_ca0659-03 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column14356_ca0659-03 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column14356_ca0659-03 > .kt-inside-inner-col{flex-direction:column;}.kadence-column14356_ca0659-03 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column14356_ca0659-03 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column14356_ca0659-03{position:relative;}@media all and (max-width: 1024px){.kadence-column14356_ca0659-03 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column14356_ca0659-03 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column14356_ca0659-03\"><div class=\"kt-inside-inner-col\"><\/div><\/div>\n\n<\/div><\/div>\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n\n\n\n<div class=\"wp-block-group is-nowrap is-layout-flex wp-container-core-group-is-layout-ad2f72ca wp-block-group-is-layout-flex\">\n<p><strong>The advanced protein biotechnology consortium: A model for fostering economic growth and mitigating brain drain in Eastern Slovakia<\/strong><\/p>\n<\/div>\n\n\n\n<p><strong>Project code:&nbsp;<\/strong>09I02-03-V01-00021<\/p>\n\n\n\n<p>Acronym:&nbsp;<strong>APBC<\/strong><\/p>\n\n\n\n<p>The Advanced Protein Biotechnology Consortium is a project aimed at an international collaborative R&amp;D model with excellent academic partners to address economic and social challenges in Slovakia while effectively mitigating the brain drain from Eastern Slovakia. The APBC project is strategically designed to foster sustainable development by leveraging the potential of protein biotechnology, setting up the conditions for the creation of intellectual property in the given area and the conditions to attract bio-production facilities in the long term. By focusing on this cutting-edge field, the consortium aims to drive economic growth, create high-skilled job opportunities, and enhance the overall competitiveness of Slovakia in the bio-industrial segment. Hence, APBC provides a model proof-of-principle concept for addressing the significant challenges in Slovakia, and we expect that our initiative will motivate other industrial segments as well.<\/p>\n\n\n\n<p><strong>Principal investigator:<\/strong>&nbsp;prof. RNDr. Erik Sedl\u00e1k, DrSc.<\/p>\n\n\n\n<p><strong>Period:<\/strong>&nbsp;01\/03\/2025-31\/08\/2027<\/p>\n\n\n\n<p><strong><a href=\"https:\/\/www.upjs.sk\/pracoviska\/tip\/en\/apbc\/\" target=\"_blank\" rel=\"noreferrer noopener\">Website<\/a><\/strong><\/p>\n\n\n<style>.kb-image14356_e99eb2-ef .kb-image-has-overlay:after{opacity:0.3;}<\/style>\n<figure class=\"wp-block-kadence-image kb-image14356_e99eb2-ef size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1123\" height=\"120\" src=\"https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/09\/Screenshot-2025-09-28-234346.jpg\" alt=\"\" class=\"kb-img wp-image-19806\" srcset=\"https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/09\/Screenshot-2025-09-28-234346.jpg 1123w, https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/09\/Screenshot-2025-09-28-234346-300x32.jpg 300w, https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/09\/Screenshot-2025-09-28-234346-1024x109.jpg 1024w, https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/09\/Screenshot-2025-09-28-234346-768x82.jpg 768w\" sizes=\"auto, (max-width: 1123px) 100vw, 1123px\" \/><\/figure>\n\n\n<style>.wp-block-kadence-spacer.kt-block-spacer-14356_114089-4f .kt-block-spacer{height:20px;}.wp-block-kadence-spacer.kt-block-spacer-14356_114089-4f .kt-divider{border-top-width:1px;height:1px;border-top-color:#C19152;width:100%;border-top-style:solid;}<\/style>\n<div class=\"wp-block-kadence-spacer aligncenter kt-block-spacer-14356_114089-4f\"><div class=\"kt-block-spacer kt-block-spacer-halign-center\"><hr class=\"kt-divider\"\/><\/div><\/div>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Project ExCasProt<\/h2>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"842\" height=\"332\" src=\"https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2024\/08\/ExCasProt.png\" alt=\"\" class=\"wp-image-18432\" style=\"width:286px;height:auto\" srcset=\"https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2024\/08\/ExCasProt.png 842w, https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2024\/08\/ExCasProt-300x118.png 300w, https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2024\/08\/ExCasProt-768x303.png 768w\" sizes=\"auto, (max-width: 842px) 100vw, 842px\" \/><\/figure>\n\n\n\n<p><\/p>\n\n\n\n<p><strong>Fostering high scientific quality in protein research in Eastern Slovakia<\/strong><\/p>\n\n\n\n<p><strong>Project code:<\/strong> 09I01-03-V04-00041<\/p>\n\n\n\n<p>The main goal of the presented ExCasProt project is to use directed evolution methods to develop and identify soluble analogues of GPCR proteins, which will lead to easier manipulation of them and a better understanding of their structure and function.<\/p>\n\n\n\n<p>G-protein-coupled receptors (GPCRs) represent an important group of membrane proteins. They play a key role in the organism and disruption of their signaling pathway is associated with a number of diseases, therefore they are a relevant target of the pharmaceutical industry. Drug design based on detailed knowledge of the structure of protein-ligand complexes is one of the most effective approaches in current drug research. For GPCRs, the number of available structures is limited due to the lack of structural data caused by complications related to their production and isolation in native form. The main goal of the presented ExCasProt project is to develop and identify soluble analogues of GPCR proteins using directed evolution methods, which will lead to easier manipulation of them, better understanding of their structure and function. Success in this specific case will serve as a proof of principle that could be applicable to other proteins from the GPCR class.<\/p>\n\n\n\n<p><strong><strong>Principal investigator:<\/strong>&nbsp;<\/strong>Mgr. M\u00e1ria Tomkov\u00e1, PhD.<\/p>\n\n\n\n<p><strong>Period:&nbsp;<\/strong>2\/2024 \u2013 6\/2026<\/p>\n\n\n<style>.kb-row-layout-id14356_16a218-ba > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id14356_16a218-ba > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id14356_16a218-ba > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);padding-top:var(--global-kb-spacing-xxs, 0.5rem);padding-bottom:var(--global-kb-spacing-sm, 1.5rem);}.kb-row-layout-id14356_16a218-ba > .kt-row-column-wrap > div:not(.added-for-specificity){grid-column:initial;}.kb-row-layout-id14356_16a218-ba > .kt-row-column-wrap{grid-template-columns:repeat(4, minmax(0, 1fr));}.kb-row-layout-id14356_16a218-ba > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id14356_16a218-ba > .kt-row-column-wrap > div:not(.added-for-specificity){grid-column:initial;}}@media all and (max-width: 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srcset=\"https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/06\/EN_Funded-by-the-EU-NextGenEU_BLACK-300x75.png 300w, https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/06\/EN_Funded-by-the-EU-NextGenEU_BLACK-1024x255.png 1024w, https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/06\/EN_Funded-by-the-EU-NextGenEU_BLACK-768x191.png 768w, https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/06\/EN_Funded-by-the-EU-NextGenEU_BLACK-1536x382.png 1536w, https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/06\/EN_Funded-by-the-EU-NextGenEU_BLACK-2048x510.png 2048w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/figure>\n<\/div><\/div>\n\n\n<style>.kadence-column14356_4bae79-a8 > .kt-inside-inner-col,.kadence-column14356_4bae79-a8 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column14356_4bae79-a8 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 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srcset=\"https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/06\/POO_logo_angl.png 1302w, https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/06\/POO_logo_angl-300x127.png 300w, https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/06\/POO_logo_angl-1024x433.png 1024w, https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/06\/POO_logo_angl-768x325.png 768w\" sizes=\"auto, (max-width: 1302px) 100vw, 1302px\" \/><\/figure>\n<\/div><\/div>\n\n\n<style>.kadence-column14356_53ba2f-f6 > .kt-inside-inner-col,.kadence-column14356_53ba2f-f6 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column14356_53ba2f-f6 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column14356_53ba2f-f6 > .kt-inside-inner-col{flex-direction:column;}.kadence-column14356_53ba2f-f6 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column14356_53ba2f-f6 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column14356_53ba2f-f6{position:relative;}@media all and (max-width: 1024px){.kadence-column14356_53ba2f-f6 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column14356_53ba2f-f6 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column14356_53ba2f-f6\"><div class=\"kt-inside-inner-col\"><\/div><\/div>\n\n\n<style>.kadence-column14356_77dbea-f9 > .kt-inside-inner-col,.kadence-column14356_77dbea-f9 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column14356_77dbea-f9 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column14356_77dbea-f9 > .kt-inside-inner-col{flex-direction:column;}.kadence-column14356_77dbea-f9 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column14356_77dbea-f9 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column14356_77dbea-f9{position:relative;}@media all and (max-width: 1024px){.kadence-column14356_77dbea-f9 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column14356_77dbea-f9 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column14356_77dbea-f9\"><div class=\"kt-inside-inner-col\"><\/div><\/div>\n\n<\/div><\/div>\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>PROJECTS SUPPORTED BY THE RECOVERY AND RESILIENCE PLAN Project APBC The advanced protein biotechnology consortium: A model for fostering economic growth and mitigating brain drain in Eastern Slovakia Project code:&nbsp;09I02-03-V01-00021 Acronym:&nbsp;APBC The Advanced Protein Biotechnology Consortium is a project aimed at an international collaborative R&amp;D model with excellent academic partners to address economic and social &hellip; <a href=\"https:\/\/www.upjs.sk\/pracoviska\/tip\/en\/sp\/\">Continued<\/a><\/p>\n","protected":false},"author":1,"featured_media":18812,"parent":0,"menu_order":11,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_editorskit_title_hidden":false,"_editorskit_reading_time":1,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","footnotes":""},"class_list":["post-14356","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":{"acf_link_na_externy_obsah":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Significant Projects - Technologick\u00fd a inova\u010dn\u00fd park | UPJ\u0160<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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