{"id":18986,"date":"2025-06-05T11:08:51","date_gmt":"2025-06-05T11:08:51","guid":{"rendered":"https:\/\/www.upjs.sk\/pracoviska\/tip\/?page_id=18986"},"modified":"2025-10-19T20:29:35","modified_gmt":"2025-10-19T20:29:35","slug":"research-activities-apbc","status":"publish","type":"page","link":"https:\/\/www.upjs.sk\/pracoviska\/tip\/en\/apbc\/research-activities-apbc\/","title":{"rendered":"RESEARCH ACTIVITIES APBC"},"content":{"rendered":"\n
<\/td>
Protein Engineering of Staphylokinases as New Promising Thrombolytics<\/strong><\/strong><\/td>		<\/td><\/tr><\/tbody>
<\/td><\/td><\/td><\/tr><\/tfoot><\/table><\/figure>\n\n\n\n

This activity involves the modification and optimization of staphylokinases with the aim of developing more effective thrombolytic agents for medical applications.<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n
<\/td>Protein Engineering of Dehalogenases and Development of a New Generation of Stable Fibroblast Growth Factor 2<\/strong><\/strong><\/strong><\/td><\/td><\/tr><\/tbody>
<\/td><\/td><\/td><\/tr><\/tfoot><\/table><\/figure>\n\n\n\n

This activity focuses on engineering dehalogenase enzymes and stabilizing fibroblast growth factor 2 (FGF2) to enhance its therapeutic potential.<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n
<\/td>
Development of New Genetically Encoded Photosensitizers<\/strong><\/strong><\/strong><\/strong><\/td>		<\/td><\/tr><\/tbody>
<\/td><\/td><\/td><\/tr><\/tfoot><\/table><\/figure>\n\n\n\n

This activity aims to create novel genetically encoded photosensitizers for applications in photodynamic therapy and imaging.<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n
<\/td>
Bioinformatics Approaches to New Photosensitive Molecules<\/strong><\/strong><\/strong><\/strong><\/strong><\/td>		<\/td><\/tr><\/tbody>
<\/td><\/td><\/td><\/tr><\/tfoot><\/table><\/figure>\n\n\n\n

This activity uses bioinformatics to analyze and predict the properties of newly developed photosensitive molecules.<\/p>\n\n\n\n

<\/td>
Spider Silk as a Promising Biomaterial<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong>
<\/td>		<\/td><\/tr><\/tbody>
<\/td><\/td><\/td><\/tr><\/tfoot><\/table><\/figure>\n\n\n\n

This activity explores the potential of spider silk as a biomaterial for various applications, including tissue engineering and drug delivery.<\/p>\n\n\n\n

<\/td>
Molecular Mechanism of Amyloidosis<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong>
<\/td>		<\/td><\/tr><\/tbody>
<\/td><\/td><\/td><\/tr><\/tfoot><\/table><\/figure>\n\n\n\n

This activity focuses on studying amyloidosis, a group of disorders characterized by abnormal protein aggregation, to gain insights into disease mechanisms and potential therapeutic interventions.<\/p>\n\n\n\n

<\/td>Conformational and Colloidal Stability of Immunoglobulins and Pathological Light Chains of IgGs<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/td><\/td><\/tr><\/tbody>
<\/td><\/td><\/td><\/tr><\/tfoot><\/table><\/figure>\n\n\n\n

This activity investigates the stability of immunoglobulins and pathological light chains to better understand their conformational and colloidal properties.<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n
<\/td>
Development of Antibodies Against Difficult Targets<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong>
<\/td>		<\/td><\/tr><\/tbody>
<\/td><\/td><\/td><\/tr><\/tfoot><\/table><\/figure>\n\n\n\n

This activity aims to deliver specific molecular binders for research applications, with potential use as diagnostic and\/or therapeutic tools in human diseases.<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n
<\/td>Production of Proteins in Mammalian Cell Lines<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/td>

<\/td><\/tr><\/tbody>
<\/td><\/td><\/td><\/tr><\/tfoot><\/table><\/figure>\n\n\n\n

This activity seeks to establish conditions for small- and medium-scale production of proteins developed in previous tasks, as a first step toward their commercial application.<\/p>\n\n\n\n

<\/td>
Molecular Structure of Biotechnology Candidates<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong>
<\/td>

<\/td><\/tr><\/tbody>
<\/td><\/td><\/td><\/tr><\/tfoot><\/table><\/figure>\n\n\n\n

This activity studies the structure of developed proteins, primarily using X-ray crystallography.<\/p>\n","protected":false},"excerpt":{"rendered":"

Protein Engineering of Staphylokinases as New Promising Thrombolytics This activity involves the modification and optimization of staphylokinases with the aim of developing more effective thrombolytic agents for medical applications. Protein Engineering of Dehalogenases and Development of a New Generation of Stable Fibroblast Growth Factor 2 This activity focuses on engineering dehalogenase enzymes and stabilizing fibroblast … Continued<\/a><\/p>\n","protected":false},"author":16,"featured_media":0,"parent":18860,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","footnotes":""},"class_list":["post-18986","page","type-page","status-publish","hentry"],"acf":{"acf_link_na_externy_obsah":""},"yoast_head":"\nRESEARCH ACTIVITIES APBC - Technologick\u00fd a inova\u010dn\u00fd park | UPJ\u0160<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.upjs.sk\/pracoviska\/tip\/en\/apbc\/research-activities-apbc\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"RESEARCH ACTIVITIES APBC - Technologick\u00fd a inova\u010dn\u00fd park | UPJ\u0160\" \/>\n<meta property=\"og:description\" content=\"Protein Engineering of Staphylokinases as New Promising Thrombolytics This activity involves the modification and optimization of staphylokinases with the aim of developing more effective thrombolytic agents for medical applications. Protein Engineering of Dehalogenases and Development of a New Generation of Stable Fibroblast Growth Factor 2 This activity focuses on engineering dehalogenase enzymes and stabilizing fibroblast … Continued\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.upjs.sk\/pracoviska\/tip\/en\/apbc\/research-activities-apbc\/\" \/>\n<meta property=\"og:site_name\" content=\"Technologick\u00fd a inova\u010dn\u00fd park | UPJ\u0160\" \/>\n<meta property=\"article:modified_time\" content=\"2025-10-19T20:29:35+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/10\/SAK.png\" \/>\n\t<meta property=\"og:image:width\" content=\"3280\" \/>\n\t<meta property=\"og:image:height\" content=\"1430\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.upjs.sk\/pracoviska\/tip\/en\/apbc\/research-activities-apbc\/\",\"url\":\"https:\/\/www.upjs.sk\/pracoviska\/tip\/en\/apbc\/research-activities-apbc\/\",\"name\":\"RESEARCH ACTIVITIES APBC - Technologick\u00fd a inova\u010dn\u00fd park | UPJ\u0160\",\"isPartOf\":{\"@id\":\"https:\/\/www.upjs.sk\/pracoviska\/tip\/en\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.upjs.sk\/pracoviska\/tip\/en\/apbc\/research-activities-apbc\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.upjs.sk\/pracoviska\/tip\/en\/apbc\/research-activities-apbc\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/10\/SAK-1024x446.png\",\"datePublished\":\"2025-06-05T11:08:51+00:00\",\"dateModified\":\"2025-10-19T20:29:35+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.upjs.sk\/pracoviska\/tip\/en\/apbc\/research-activities-apbc\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.upjs.sk\/pracoviska\/tip\/en\/apbc\/research-activities-apbc\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.upjs.sk\/pracoviska\/tip\/en\/apbc\/research-activities-apbc\/#primaryimage\",\"url\":\"https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/10\/SAK-1024x446.png\",\"contentUrl\":\"https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/10\/SAK-1024x446.png\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.upjs.sk\/pracoviska\/tip\/en\/apbc\/research-activities-apbc\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.upjs.sk\/pracoviska\/tip\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"APBC\",\"item\":\"https:\/\/www.upjs.sk\/pracoviska\/tip\/en\/apbc\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"RESEARCH ACTIVITIES APBC\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.upjs.sk\/pracoviska\/tip\/en\/#website\",\"url\":\"https:\/\/www.upjs.sk\/pracoviska\/tip\/en\/\",\"name\":\"Technologick\u00fd a inova\u010dn\u00fd park | UPJ\u0160\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/www.upjs.sk\/pracoviska\/tip\/en\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.upjs.sk\/pracoviska\/tip\/en\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.upjs.sk\/pracoviska\/tip\/en\/#organization\",\"name\":\"Technologick\u00fd a inova\u010dn\u00fd park | UPJ\u0160\",\"url\":\"https:\/\/www.upjs.sk\/pracoviska\/tip\/en\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.upjs.sk\/pracoviska\/tip\/en\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2023\/02\/TIP_ENG.svg\",\"contentUrl\":\"https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2023\/02\/TIP_ENG.svg\",\"width\":500,\"height\":138,\"caption\":\"Technologick\u00fd a inova\u010dn\u00fd park | UPJ\u0160\"},\"image\":{\"@id\":\"https:\/\/www.upjs.sk\/pracoviska\/tip\/en\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"RESEARCH ACTIVITIES APBC - Technologick\u00fd a inova\u010dn\u00fd park | UPJ\u0160","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.upjs.sk\/pracoviska\/tip\/en\/apbc\/research-activities-apbc\/","og_locale":"en_US","og_type":"article","og_title":"RESEARCH ACTIVITIES APBC - Technologick\u00fd a inova\u010dn\u00fd park | UPJ\u0160","og_description":"Protein Engineering of Staphylokinases as New Promising Thrombolytics This activity involves the modification and optimization of staphylokinases with the aim of developing more effective thrombolytic agents for medical applications. Protein Engineering of Dehalogenases and Development of a New Generation of Stable Fibroblast Growth Factor 2 This activity focuses on engineering dehalogenase enzymes and stabilizing fibroblast … Continued","og_url":"https:\/\/www.upjs.sk\/pracoviska\/tip\/en\/apbc\/research-activities-apbc\/","og_site_name":"Technologick\u00fd a inova\u010dn\u00fd park | UPJ\u0160","article_modified_time":"2025-10-19T20:29:35+00:00","og_image":[{"width":3280,"height":1430,"url":"https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/10\/SAK.png","type":"image\/png"}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.upjs.sk\/pracoviska\/tip\/en\/apbc\/research-activities-apbc\/","url":"https:\/\/www.upjs.sk\/pracoviska\/tip\/en\/apbc\/research-activities-apbc\/","name":"RESEARCH ACTIVITIES APBC - Technologick\u00fd a inova\u010dn\u00fd park | UPJ\u0160","isPartOf":{"@id":"https:\/\/www.upjs.sk\/pracoviska\/tip\/en\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.upjs.sk\/pracoviska\/tip\/en\/apbc\/research-activities-apbc\/#primaryimage"},"image":{"@id":"https:\/\/www.upjs.sk\/pracoviska\/tip\/en\/apbc\/research-activities-apbc\/#primaryimage"},"thumbnailUrl":"https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/10\/SAK-1024x446.png","datePublished":"2025-06-05T11:08:51+00:00","dateModified":"2025-10-19T20:29:35+00:00","breadcrumb":{"@id":"https:\/\/www.upjs.sk\/pracoviska\/tip\/en\/apbc\/research-activities-apbc\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.upjs.sk\/pracoviska\/tip\/en\/apbc\/research-activities-apbc\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.upjs.sk\/pracoviska\/tip\/en\/apbc\/research-activities-apbc\/#primaryimage","url":"https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/10\/SAK-1024x446.png","contentUrl":"https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/10\/SAK-1024x446.png"},{"@type":"BreadcrumbList","@id":"https:\/\/www.upjs.sk\/pracoviska\/tip\/en\/apbc\/research-activities-apbc\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.upjs.sk\/pracoviska\/tip\/en\/"},{"@type":"ListItem","position":2,"name":"APBC","item":"https:\/\/www.upjs.sk\/pracoviska\/tip\/en\/apbc\/"},{"@type":"ListItem","position":3,"name":"RESEARCH ACTIVITIES APBC"}]},{"@type":"WebSite","@id":"https:\/\/www.upjs.sk\/pracoviska\/tip\/en\/#website","url":"https:\/\/www.upjs.sk\/pracoviska\/tip\/en\/","name":"Technologick\u00fd a inova\u010dn\u00fd park | UPJ\u0160","description":"","publisher":{"@id":"https:\/\/www.upjs.sk\/pracoviska\/tip\/en\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.upjs.sk\/pracoviska\/tip\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.upjs.sk\/pracoviska\/tip\/en\/#organization","name":"Technologick\u00fd a inova\u010dn\u00fd park | UPJ\u0160","url":"https:\/\/www.upjs.sk\/pracoviska\/tip\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.upjs.sk\/pracoviska\/tip\/en\/#\/schema\/logo\/image\/","url":"https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2023\/02\/TIP_ENG.svg","contentUrl":"https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2023\/02\/TIP_ENG.svg","width":500,"height":138,"caption":"Technologick\u00fd a inova\u010dn\u00fd park | UPJ\u0160"},"image":{"@id":"https:\/\/www.upjs.sk\/pracoviska\/tip\/en\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/www.upjs.sk\/pracoviska\/tip\/en\/wp-json\/wp\/v2\/pages\/18986","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.upjs.sk\/pracoviska\/tip\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.upjs.sk\/pracoviska\/tip\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.upjs.sk\/pracoviska\/tip\/en\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/www.upjs.sk\/pracoviska\/tip\/en\/wp-json\/wp\/v2\/comments?post=18986"}],"version-history":[{"count":8,"href":"https:\/\/www.upjs.sk\/pracoviska\/tip\/en\/wp-json\/wp\/v2\/pages\/18986\/revisions"}],"predecessor-version":[{"id":20288,"href":"https:\/\/www.upjs.sk\/pracoviska\/tip\/en\/wp-json\/wp\/v2\/pages\/18986\/revisions\/20288"}],"up":[{"embeddable":true,"href":"https:\/\/www.upjs.sk\/pracoviska\/tip\/en\/wp-json\/wp\/v2\/pages\/18860"}],"wp:attachment":[{"href":"https:\/\/www.upjs.sk\/pracoviska\/tip\/en\/wp-json\/wp\/v2\/media?parent=18986"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}