{"id":13163,"date":"2021-10-22T10:26:43","date_gmt":"2021-10-22T10:26:43","guid":{"rendered":"https:\/\/www.upjs.sk\/pracoviska\/tip\/root\/vp\/"},"modified":"2025-09-28T21:27:50","modified_gmt":"2025-09-28T21:27:50","slug":"vp","status":"publish","type":"page","link":"https:\/\/www.upjs.sk\/pracoviska\/tip\/vp\/","title":{"rendered":"V\u00fdznamn\u00e9 projekty"},"content":{"rendered":"\n<h3 class=\"wp-block-heading\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-cierna-color\">PROJEKTY Z PL\u00c1NU OBNOVY A ODOLNOSTI<\/mark><\/h3>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Projekt APBC<\/h2>\n\n\n<style>.kb-row-layout-id13163_aae600-c5 > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id13163_aae600-c5 > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id13163_aae600-c5 > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-sm, 1.5rem);grid-template-columns:repeat(2, minmax(0, 1fr));}.kb-row-layout-id13163_aae600-c5 > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id13163_aae600-c5 > .kt-row-column-wrap{grid-template-columns:repeat(2, minmax(0, 1fr));}}@media all and (max-width: 767px){.kb-row-layout-id13163_aae600-c5 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id13163_aae600-c5 alignnone wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-2-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top\">\n<style>.kadence-column13163_e2e90d-c3 > .kt-inside-inner-col,.kadence-column13163_e2e90d-c3 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column13163_e2e90d-c3 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column13163_e2e90d-c3 > .kt-inside-inner-col{flex-direction:column;}.kadence-column13163_e2e90d-c3 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column13163_e2e90d-c3 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column13163_e2e90d-c3{position:relative;}@media all and (max-width: 1024px){.kadence-column13163_e2e90d-c3 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column13163_e2e90d-c3 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column13163_e2e90d-c3\"><div class=\"kt-inside-inner-col\">\n<figure class=\"wp-block-image size-full is-resized\"><a href=\"https:\/\/www.upjs.sk\/pracoviska\/tip\/apbc\/\"><img loading=\"lazy\" decoding=\"async\" width=\"4918\" height=\"2112\" src=\"https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/06\/color_transparent_APBC.png\" alt=\"\" class=\"wp-image-18811\" style=\"width:286px;height:auto\" srcset=\"https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/06\/color_transparent_APBC.png 4918w, https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/06\/color_transparent_APBC-300x129.png 300w, https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/06\/color_transparent_APBC-1024x440.png 1024w, https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/06\/color_transparent_APBC-768x330.png 768w, https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/06\/color_transparent_APBC-1536x660.png 1536w, https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/06\/color_transparent_APBC-2048x879.png 2048w\" sizes=\"auto, (max-width: 4918px) 100vw, 4918px\" \/><\/a><\/figure>\n<\/div><\/div>\n\n\n<style>.kadence-column13163_c9db48-57 > .kt-inside-inner-col,.kadence-column13163_c9db48-57 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column13163_c9db48-57 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column13163_c9db48-57 > .kt-inside-inner-col{flex-direction:column;}.kadence-column13163_c9db48-57 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column13163_c9db48-57 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column13163_c9db48-57{position:relative;}@media all and (max-width: 1024px){.kadence-column13163_c9db48-57 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column13163_c9db48-57 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column13163_c9db48-57\"><div class=\"kt-inside-inner-col\"><\/div><\/div>\n\n<\/div><\/div>\n\n\n<p><strong>Konzorcium pokro\u010dil\u00fdch prote\u00ednov\u00fdch biotechnol\u00f3gi\u00ed: Model pre podporu ekonomick\u00e9ho rastu a zmiernenie \u00faniku mozgov na v\u00fdchodnom Slovensku<\/strong><\/p>\n\n\n\n<p><strong>K\u00f3d projektu:&nbsp;<\/strong>09I02-03-V01-00021<\/p>\n\n\n\n<p>Akronym:&nbsp;<strong>APBC<\/strong><\/p>\n\n\n\n<p>Konzorcium pokro\u010dil\u00fdch prote\u00ednov\u00fdch biotechnol\u00f3gi\u00ed (APBC) je projekt zameran\u00fd na medzin\u00e1rodn\u00fd model spolupr\u00e1ce v oblasti v\u00fdskumu a v\u00fdvoja s vynikaj\u00facimi akademick\u00fdmi partnermi s cie\u013eom rie\u0161i\u0165 ekonomick\u00e9 a soci\u00e1lne v\u00fdzvy na Slovensku a z\u00e1rove\u0148 \u00fa\u010dinne zmierni\u0165 \u00fanik mozgov z v\u00fdchodn\u00e9ho Slovenska. Projekt APBC je strategicky navrhnut\u00fd tak, aby podporoval trvalo udr\u017eate\u013en\u00fd rozvoj vyu\u017e\u00edvan\u00edm potenci\u00e1lu prote\u00ednovej biotechnol\u00f3gie, vytv\u00e1ran\u00edm podmienok pre tvorbu intelektu\u00e1lneho vlastn\u00edctva v&nbsp;danej oblasti a podmienok na dlhodob\u00e9 pril\u00e1kanie zariaden\u00ed na bioprodukciu. Zameran\u00edm sa na t\u00fato \u0161pi\u010dkov\u00fa oblas\u0165 chce konzorcium stimulova\u0165 ekonomick\u00fd rast, vytv\u00e1ra\u0165 vysokokvalifikovan\u00e9 pracovn\u00e9 pr\u00edle\u017eitosti a zvy\u0161ova\u0165 celkov\u00fa konkurencieschopnos\u0165 Slovenska v&nbsp;biotechnologickom segmente. APBC pon\u00faka vzorov\u00fd koncept overenia princ\u00edpov na rie\u0161enie v\u00fdznamn\u00fdch v\u00fdziev na Slovensku a o\u010dak\u00e1vame, \u017ee na\u0161a iniciat\u00edva bude motivova\u0165 aj \u010fal\u0161ie priemyseln\u00e9 segmenty.<\/p>\n\n\n\n<p><strong><strong>Hlavn\u00fd rie\u0161ite\u013e:<\/strong><\/strong>&nbsp;prof. RNDr. Erik Sedl\u00e1k, DrSc.<\/p>\n\n\n\n<p><strong><strong>Doba trvania projektu:<\/strong><\/strong>&nbsp;01\/03\/2025-31\/08\/2027<\/p>\n\n\n\n<p><strong><a href=\"https:\/\/www.upjs.sk\/pracoviska\/tip\/apbc\/\">Webov\u00e1 str\u00e1nka<\/a><\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" width=\"1943\" height=\"194\" src=\"https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/09\/Loga-2025-aktualizovane_SK.png\" alt=\"\" class=\"wp-image-19777\" srcset=\"https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/09\/Loga-2025-aktualizovane_SK.png 1943w, https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/09\/Loga-2025-aktualizovane_SK-300x30.png 300w, https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/09\/Loga-2025-aktualizovane_SK-1024x102.png 1024w, https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/09\/Loga-2025-aktualizovane_SK-768x77.png 768w, https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/09\/Loga-2025-aktualizovane_SK-1536x153.png 1536w\" sizes=\"auto, (max-width: 1943px) 100vw, 1943px\" \/><\/figure>\n\n\n<style>.kb-row-layout-id13163_895f70-3c > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id13163_895f70-3c > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id13163_895f70-3c > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);padding-top:var(--global-kb-spacing-xxs, 0.5rem);padding-bottom:var(--global-kb-spacing-sm, 1.5rem);}.kb-row-layout-id13163_895f70-3c > .kt-row-column-wrap > div:not(.added-for-specificity){grid-column:initial;}.kb-row-layout-id13163_895f70-3c > .kt-row-column-wrap{grid-template-columns:repeat(4, minmax(0, 1fr));}.kb-row-layout-id13163_895f70-3c > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id13163_895f70-3c > .kt-row-column-wrap > div:not(.added-for-specificity){grid-column:initial;}}@media all and (max-width: 1024px){.kb-row-layout-id13163_895f70-3c > .kt-row-column-wrap{grid-template-columns:repeat(4, minmax(0, 1fr));}}@media all and (max-width: 767px){.kb-row-layout-id13163_895f70-3c > .kt-row-column-wrap > div:not(.added-for-specificity){grid-column:initial;}.kb-row-layout-id13163_895f70-3c > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id13163_895f70-3c alignnone wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-4-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top\">\n<style>.kadence-column13163_34c919-a6 > .kt-inside-inner-col,.kadence-column13163_34c919-a6 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column13163_34c919-a6 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column13163_34c919-a6 > .kt-inside-inner-col{flex-direction:column;}.kadence-column13163_34c919-a6 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column13163_34c919-a6 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column13163_34c919-a6{position:relative;}@media all and (max-width: 1024px){.kadence-column13163_34c919-a6 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column13163_34c919-a6 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column13163_34c919-a6\"><div class=\"kt-inside-inner-col\"><\/div><\/div>\n\n\n<style>.kadence-column13163_f0ac99-5e > .kt-inside-inner-col,.kadence-column13163_f0ac99-5e > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column13163_f0ac99-5e > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column13163_f0ac99-5e > .kt-inside-inner-col{flex-direction:column;}.kadence-column13163_f0ac99-5e > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column13163_f0ac99-5e > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column13163_f0ac99-5e{position:relative;}@media all and (max-width: 1024px){.kadence-column13163_f0ac99-5e > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column13163_f0ac99-5e > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column13163_f0ac99-5e\"><div class=\"kt-inside-inner-col\"><\/div><\/div>\n\n\n<style>.kadence-column13163_0ff365-e4 > .kt-inside-inner-col,.kadence-column13163_0ff365-e4 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column13163_0ff365-e4 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column13163_0ff365-e4 > .kt-inside-inner-col{flex-direction:column;}.kadence-column13163_0ff365-e4 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column13163_0ff365-e4 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column13163_0ff365-e4{position:relative;}@media all and (max-width: 1024px){.kadence-column13163_0ff365-e4 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column13163_0ff365-e4 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column13163_0ff365-e4\"><div class=\"kt-inside-inner-col\"><\/div><\/div>\n\n\n<style>.kadence-column13163_f99275-3f > .kt-inside-inner-col,.kadence-column13163_f99275-3f > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column13163_f99275-3f > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column13163_f99275-3f > .kt-inside-inner-col{flex-direction:column;}.kadence-column13163_f99275-3f > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column13163_f99275-3f > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column13163_f99275-3f{position:relative;}@media all and (max-width: 1024px){.kadence-column13163_f99275-3f > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column13163_f99275-3f > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column13163_f99275-3f\"><div class=\"kt-inside-inner-col\"><\/div><\/div>\n\n<\/div><\/div>\n\n<style>.wp-block-kadence-spacer.kt-block-spacer-13163_bb2983-ef .kt-block-spacer{height:20px;}.wp-block-kadence-spacer.kt-block-spacer-13163_bb2983-ef .kt-divider{border-top-width:1px;height:1px;border-top-color:#C19152;width:100%;border-top-style:solid;}<\/style>\n<div class=\"wp-block-kadence-spacer aligncenter kt-block-spacer-13163_bb2983-ef\"><div class=\"kt-block-spacer kt-block-spacer-halign-center\"><hr class=\"kt-divider\"\/><\/div><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Projekt ExCasProt<\/h2>\n\n\n\n<div class=\"wp-block-group is-nowrap is-layout-flex wp-container-core-group-is-layout-ad2f72ca wp-block-group-is-layout-flex\">\n<p><\/p>\n<\/div>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"842\" height=\"332\" src=\"https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2024\/08\/ExCasProt.png\" alt=\"\" class=\"wp-image-18432\" style=\"width:286px;height:auto\" srcset=\"https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2024\/08\/ExCasProt.png 842w, https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2024\/08\/ExCasProt-300x118.png 300w, https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2024\/08\/ExCasProt-768x303.png 768w\" sizes=\"auto, (max-width: 842px) 100vw, 842px\" \/><\/figure>\n\n\n\n<p><strong>Podpora rozvoja biotechnologick\u00e9ho v\u00fdskumu prote\u00ednov na v\u00fdchodnom&nbsp;Slovensku<\/strong><\/p>\n\n\n\n<p><strong>K\u00f3d projektu:<\/strong>&nbsp;09I01-03-V04-00041<\/p>\n\n\n\n<p>Hlav\u00fdm cie\u013eom predkladan\u00e9ho projektu ExCasProt je pomocou met\u00f3d riadenej evol\u00facie vyvin\u00fa\u0165 a identifikova\u0165 solubiln\u00e9 anal\u00f3gy GPCR prote\u00ednov, \u010do povedie k jednoduch\u0161ej manipul\u00e1cii s nimi, lep\u0161iemu pochopeniu ich \u0161trukt\u00fary a funkcie.<\/p>\n\n\n\n<p>Receptory spojen\u00e9 s G-prote\u00ednmi (GPCR) predstavuj\u00fa d\u00f4le\u017eit\u00fa skupinu membr\u00e1nov\u00fdch prote\u00ednov. V organizme zohr\u00e1vaj\u00fa k\u013e\u00fa\u010dov\u00fa \u00falohu a naru\u0161enie ich sign\u00e1lnej dr\u00e1hy je spojen\u00e9 s mno\u017estvom ochoren\u00ed, preto s\u00fa relevantn\u00fdm cie\u013eom farmaceutick\u00e9ho priemyslu. Dizajn lie\u010div zalo\u017een\u00fd na detailnom poznan\u00ed \u0161trukt\u00fary komplexov prote\u00edn-ligand je jedn\u00fdm z najefekt\u00edvnej\u0161\u00edch pr\u00edstupov v s\u00fa\u010dasnom v\u00fdskume liekov. U GPCR je po\u010det dostupn\u00fdch \u0161trukt\u00far obmedzen\u00fd v d\u00f4sledku nedostatku \u0161trukt\u00farnych \u00fadajov sp\u00f4soben\u00fdch komplik\u00e1ciami s\u00favisiacimi s ich produkciou a izol\u00e1ciou v nat\u00edvnej forme. Hlav\u00fdm cie\u013eom predkladan\u00e9ho projektu ExCasProt je pomocou met\u00f3d riadenej evol\u00facie vyvin\u00fa\u0165 a identifikova\u0165 solubiln\u00e9 anal\u00f3gy GPCR prote\u00ednov, \u010do povedie k jednoduch\u0161ej manipul\u00e1cii s nimi, lep\u0161iemu pochopeniu ich \u0161trukt\u00fary a funkcie. \u00daspech v konkr\u00e9tnom pr\u00edpade n\u00e1m posl\u00fa\u017ei ako d\u00f4kaz princ\u00edpu, ktor\u00fd by mohol by\u0165 aplikovate\u013en\u00fd aj na \u010fal\u0161ie prote\u00edny z triedy GPCR.<\/p>\n\n\n\n<p><strong>Hlavn\u00fd rie\u0161ite\u013e:&nbsp;<\/strong>Mgr. M\u00e1ria Tomkov\u00e1, PhD.<\/p>\n\n\n\n<p><strong>Doba trvania projektu:&nbsp;<\/strong>2\/2024 \u2013 6\/2026<\/p>\n\n\n<style>.kb-row-layout-id13163_3fa29a-18 > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id13163_3fa29a-18 > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id13163_3fa29a-18 > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);padding-top:var(--global-kb-spacing-xxs, 0.5rem);padding-bottom:var(--global-kb-spacing-sm, 1.5rem);}.kb-row-layout-id13163_3fa29a-18 > .kt-row-column-wrap > div:not(.added-for-specificity){grid-column:initial;}.kb-row-layout-id13163_3fa29a-18 > .kt-row-column-wrap{grid-template-columns:repeat(4, minmax(0, 1fr));}.kb-row-layout-id13163_3fa29a-18 > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id13163_3fa29a-18 > .kt-row-column-wrap > div:not(.added-for-specificity){grid-column:initial;}}@media all 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