{"id":19046,"date":"2025-06-05T11:08:51","date_gmt":"2025-06-05T11:08:51","guid":{"rendered":"https:\/\/www.upjs.sk\/pracoviska\/tip\/apbc\/research-activities-apbc\/"},"modified":"2025-11-13T15:32:22","modified_gmt":"2025-11-13T15:32:22","slug":"vyskumne-aktivity-apbc","status":"publish","type":"page","link":"https:\/\/www.upjs.sk\/pracoviska\/tip\/apbc\/vyskumne-aktivity-apbc\/","title":{"rendered":"V\u00ddSKUMN\u00c9 AKTIVITY APBC"},"content":{"rendered":"\n<figure class=\"wp-block-table is-style-stripes\"><table class=\"has-fixed-layout\"><tbody><tr><td><\/td><td class=\"has-text-align-center\" data-align=\"center\"><br><strong>Prote\u00ednov\u00e9 in\u017einierstvo stafylokin\u00e1z ako nov\u00fdch s\u013eubn\u00fdch trombolyt\u00edk<\/strong><br><\/td><td><\/td><\/tr><\/tbody><tfoot><tr><td><\/td><td class=\"has-text-align-center\" data-align=\"center\"><\/td><td><\/td><\/tr><\/tfoot><\/table><\/figure>\n\n\n\n<p>T\u00e1to aktivita zah\u0155\u0148a modifik\u00e1ciu a optimaliz\u00e1ciu stafylokin\u00e1z s cie\u013eom vyvin\u00fa\u0165 \u00fa\u010dinnej\u0161ie trombolytick\u00e9 l\u00e1tky pre medic\u00ednske aplik\u00e1cie.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"446\" src=\"https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/10\/SAK-1024x446.png\" alt=\"\" class=\"wp-image-20032\" style=\"width:278px;height:auto\" srcset=\"https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/10\/SAK-1024x446.png 1024w, https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/10\/SAK-300x131.png 300w, https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/10\/SAK-768x335.png 768w, https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/10\/SAK-1536x670.png 1536w, https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/10\/SAK-2048x893.png 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"has-text-align-left\"><\/p>\n\n\n\n<figure class=\"wp-block-table is-style-stripes\"><table class=\"has-fixed-layout\"><tbody><tr><td><\/td><td class=\"has-text-align-center\" data-align=\"center\"><br><strong><strong>Prote\u00ednov\u00e9 in\u017einierstvo dehalogen\u00e1z a v\u00fdvoj novej gener\u00e1cie stabiln\u00e9ho fibroblastov\u00e9ho rastov\u00e9ho faktora 2<\/strong><\/strong><\/td><td><\/td><\/tr><\/tbody><tfoot><tr><td><\/td><td class=\"has-text-align-center\" data-align=\"center\"><\/td><td><\/td><\/tr><\/tfoot><\/table><\/figure>\n\n\n\n<p>V r\u00e1mci danej aktivity sa zameriavame na in\u017einierstvo enz\u00fdmov dehalogen\u00e1z a stabiliz\u00e1ciu fibroblastov\u00e9ho rastov\u00e9ho faktora 2 (FGF2) s cie\u013eom zv\u00fd\u0161i\u0165 jeho terapeutick\u00fd potenci\u00e1l.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"436\" height=\"234\" src=\"https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/10\/Screenshot-2025-10-02-073025-1-e1763046394722.jpg\" alt=\"\" class=\"wp-image-20078\" style=\"width:309px;height:auto\" srcset=\"https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/10\/Screenshot-2025-10-02-073025-1-e1763046394722.jpg 436w, https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/10\/Screenshot-2025-10-02-073025-1-e1763046394722-300x161.jpg 300w\" sizes=\"auto, (max-width: 436px) 100vw, 436px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-table is-style-stripes\"><table class=\"has-fixed-layout\"><tbody><tr><td><\/td><td class=\"has-text-align-center\" data-align=\"center\"><br><strong><strong><strong>V\u00fdvoj nov\u00fdch geneticky k\u00f3dovan\u00fdch fotosenzibiliz\u00e1torov<\/strong><\/strong><\/strong><br><\/td><td><\/td><\/tr><\/tbody><tfoot><tr><td><\/td><td class=\"has-text-align-center\" data-align=\"center\"><\/td><td><\/td><\/tr><\/tfoot><\/table><\/figure>\n\n\n\n<p>Cie\u013eom danej aktivity je vytvorenie nov\u00fdch geneticky k\u00f3dovan\u00fdch fotosenzibiliz\u00e1torov pre fotodynamick\u00fa terapiu a zobrazovacie met\u00f3dy.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"372\" height=\"186\" src=\"https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/11\/Screenshot-2025-11-13-161316.jpg\" alt=\"\" class=\"wp-image-20496\" style=\"width:354px;height:auto\" srcset=\"https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/11\/Screenshot-2025-11-13-161316.jpg 372w, https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/11\/Screenshot-2025-11-13-161316-300x150.jpg 300w\" sizes=\"auto, (max-width: 372px) 100vw, 372px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-table is-style-stripes\"><table class=\"has-fixed-layout\"><tbody><tr><td><\/td><td class=\"has-text-align-center\" data-align=\"center\"><br><strong><strong><strong><strong>Bioinformatick\u00e9 pr\u00edstupy k nov\u00fdm fotosenzit\u00edvnym molekul\u00e1m<\/strong><\/strong><\/strong><\/strong><br><\/td><td><\/td><\/tr><\/tbody><tfoot><tr><td><\/td><td class=\"has-text-align-center\" data-align=\"center\"><\/td><td><\/td><\/tr><\/tfoot><\/table><\/figure>\n\n\n\n<p>T\u00e1to aktivita vyu\u017e\u00edva bioinformatiku na anal\u00fdzu a predikciu vlastnost\u00ed novovyvinut\u00fdch fotosenzit\u00edvnych molek\u00fal.<\/p>\n\n\n\n<figure class=\"wp-block-table is-style-stripes\"><table class=\"has-fixed-layout\"><tbody><tr><td><\/td><td class=\"has-text-align-center\" data-align=\"center\"><br><strong><strong><strong><strong><strong>Pav\u00fa\u010die vl\u00e1kna ako s\u013eubn\u00fd biomateri\u00e1l<\/strong><\/strong><\/strong><\/strong><\/strong><br><\/td><td><\/td><\/tr><\/tbody><tfoot><tr><td><\/td><td class=\"has-text-align-center\" data-align=\"center\"><\/td><td><\/td><\/tr><\/tfoot><\/table><\/figure>\n\n\n\n<p>V r\u00e1mci tejto aktivity sa sk\u00fama potenci\u00e1l pav\u00fa\u010dieho hodv\u00e1bu ako biomateri\u00e1lu pre r\u00f4zne aplik\u00e1cie, vr\u00e1tane tkanivov\u00e9ho in\u017einierstva a syst\u00e9moch na transport lie\u010div.<\/p>\n\n\n\n<figure class=\"wp-block-table is-style-stripes\"><table class=\"has-fixed-layout\"><tbody><tr><td><\/td><td class=\"has-text-align-center\" data-align=\"center\"><br><strong><strong><strong><strong><strong><strong>Molekul\u00e1rny mechanizmus amyloid\u00f3zy<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><br><\/td><td><\/td><\/tr><\/tbody><tfoot><tr><td><\/td><td class=\"has-text-align-center\" data-align=\"center\"><\/td><td><\/td><\/tr><\/tfoot><\/table><\/figure>\n\n\n\n<p>\u0160t\u00fadium realizovan\u00e9 v r\u00e1mci danej aktivity sa zameriava na \u0161t\u00fadium amyloid\u00f3zy, skupiny ochoren\u00ed charakterizovan\u00fdch abnorm\u00e1lnou agreg\u00e1ciou prote\u00ednov, s cie\u013eom lep\u0161ie porozumie\u0165 mechanizmom ochorenia a n\u00e1js\u0165 mo\u017en\u00e9 terapeutick\u00e9 pr\u00edstupy.<\/p>\n\n\n\n<figure class=\"wp-block-table is-style-stripes\"><table class=\"has-fixed-layout\"><tbody><tr><td><\/td><td class=\"has-text-align-center\" data-align=\"center\"><br><strong><strong><strong><strong><strong><strong><strong>Konforma\u010dn\u00e1 a koloidn\u00e1 stabilita imunoglobul\u00ednov a patologick\u00fdch \u013eahk\u00fdch re\u0165azcov IgG<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong> <br><\/td><td><\/td><\/tr><\/tbody><tfoot><tr><td><\/td><td class=\"has-text-align-center\" data-align=\"center\"><\/td><td><\/td><\/tr><\/tfoot><\/table><\/figure>\n\n\n\n<p>Cie\u013eom tejto aktivity je \u0161t\u00fadium stability imunoglobul\u00ednov a patologick\u00fdch \u013eahk\u00fdch re\u0165azcov IgG. Cie\u013eom je lep\u0161ie porozumenie ich konforma\u010dn\u00fdch a koloidn\u00fdch vlastnost\u00ed.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"550\" src=\"https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/10\/IgG-human-1024x550.png\" alt=\"\" class=\"wp-image-20029\" style=\"width:299px;height:auto\" srcset=\"https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/10\/IgG-human-1024x550.png 1024w, https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/10\/IgG-human-300x161.png 300w, https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/10\/IgG-human-768x413.png 768w, https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/10\/IgG-human-1536x825.png 1536w, https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/10\/IgG-human-2048x1100.png 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-table is-style-stripes\"><table class=\"has-fixed-layout\"><tbody><tr><td><\/td><td class=\"has-text-align-center\" data-align=\"center\"><br><strong><strong><strong><strong><strong><strong><strong><strong>V\u00fdvoj protil\u00e1tok proti \u0165a\u017eko cielite\u013en\u00fdm molekul\u00e1m<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><br><\/td><td><br><br><br><\/td><\/tr><\/tbody><tfoot><tr><td><\/td><td class=\"has-text-align-center\" data-align=\"center\"><\/td><td><\/td><\/tr><\/tfoot><\/table><\/figure>\n\n\n\n<p><\/p>\n\n\n\n<p>V projekte sa zameriavame aj na v\u00fdvoj \u0161pecifick\u00fdch molekul\u00e1rnych v\u00e4zbov\u00fdch prote\u00ednov s potenci\u00e1lom vyu\u017eitia vo v\u00fdskume a ako diagnostick\u00e9 a\/alebo terapeutick\u00e9 n\u00e1stroje pri lie\u010dbe \u013eudsk\u00fdch ochoren\u00ed.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"446\" src=\"https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/10\/Nanobody-8XLD-1024x446.png\" alt=\"\" class=\"wp-image-20026\" style=\"width:282px;height:auto\" srcset=\"https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/10\/Nanobody-8XLD-1024x446.png 1024w, https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/10\/Nanobody-8XLD-300x131.png 300w, https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/10\/Nanobody-8XLD-768x335.png 768w, https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/10\/Nanobody-8XLD-1536x670.png 1536w, https:\/\/www.upjs.sk\/app\/uploads\/sites\/24\/2025\/10\/Nanobody-8XLD-2048x893.png 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-table is-style-stripes\"><table class=\"has-fixed-layout\"><tbody><tr><td><\/td><td class=\"has-text-align-center\" data-align=\"center\"><br><strong><strong><strong><strong><strong><strong><strong><strong><strong>Produkcia prote\u00ednov v cicav\u010d\u00edch bunkov\u00fdch l\u00edni\u00e1ch<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><br><\/td><td><br><br><br><\/td><\/tr><\/tbody><tfoot><tr><td><\/td><td class=\"has-text-align-center\" data-align=\"center\"><\/td><td><\/td><\/tr><\/tfoot><\/table><\/figure>\n\n\n\n<p>Cie\u013eom je optimalizova\u0165 podmienky pre malo- a stredno-v\u00fdrobu prote\u00ednov vyvinut\u00fdch v predch\u00e1dzaj\u00facich \u00faloh\u00e1ch, ako prv\u00fd krok k ich komer\u010dn\u00e9mu vyu\u017eitiu.<\/p>\n\n\n\n<figure class=\"wp-block-table is-style-stripes\"><table class=\"has-fixed-layout\"><tbody><tr><td><\/td><td class=\"has-text-align-center\" data-align=\"center\"><br><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong>Molekul\u00e1rna \u0161trukt\u00fara biotechnologick\u00fdch kandid\u00e1tov<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><br><\/td><td><\/td><\/tr><\/tbody><tfoot><tr><td><\/td><td class=\"has-text-align-center\" data-align=\"center\"><\/td><td><\/td><\/tr><\/tfoot><\/table><\/figure>\n\n\n\n<p>V r\u00e1mci tejto aktivity budeme sk\u00fama\u0165 \u0161trukt\u00faru vyvinut\u00fdch prote\u00ednov, predov\u0161etk\u00fdm pomocou r\u00f6ntgenovej kry\u0161talografie.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Prote\u00ednov\u00e9 in\u017einierstvo stafylokin\u00e1z ako nov\u00fdch s\u013eubn\u00fdch trombolyt\u00edk T\u00e1to aktivita zah\u0155\u0148a modifik\u00e1ciu a optimaliz\u00e1ciu stafylokin\u00e1z s cie\u013eom vyvin\u00fa\u0165 \u00fa\u010dinnej\u0161ie trombolytick\u00e9 l\u00e1tky pre medic\u00ednske aplik\u00e1cie. Prote\u00ednov\u00e9 in\u017einierstvo dehalogen\u00e1z a v\u00fdvoj novej gener\u00e1cie stabiln\u00e9ho fibroblastov\u00e9ho rastov\u00e9ho faktora 2 V r\u00e1mci danej aktivity sa zameriavame na in\u017einierstvo enz\u00fdmov dehalogen\u00e1z a stabiliz\u00e1ciu fibroblastov\u00e9ho rastov\u00e9ho faktora 2 (FGF2) s cie\u013eom zv\u00fd\u0161i\u0165 &hellip; <a href=\"https:\/\/www.upjs.sk\/pracoviska\/tip\/apbc\/vyskumne-aktivity-apbc\/\">\u010c\u00edta\u0165 \u010falej<\/a><\/p>\n","protected":false},"author":16,"featured_media":0,"parent":19037,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","footnotes":""},"class_list":["post-19046","page","type-page","status-publish","hentry"],"acf":{"acf_link_na_externy_obsah":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>V\u00ddSKUMN\u00c9 AKTIVITY APBC - Technologick\u00fd a inova\u010dn\u00fd park | UPJ\u0160<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.upjs.sk\/pracoviska\/tip\/apbc\/vyskumne-aktivity-apbc\/\" \/>\n<meta property=\"og:locale\" content=\"sk_SK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"V\u00ddSKUMN\u00c9 AKTIVITY APBC - Technologick\u00fd a inova\u010dn\u00fd park | UPJ\u0160\" \/>\n<meta property=\"og:description\" content=\"Prote\u00ednov\u00e9 in\u017einierstvo stafylokin\u00e1z ako nov\u00fdch s\u013eubn\u00fdch trombolyt\u00edk T\u00e1to aktivita zah\u0155\u0148a modifik\u00e1ciu a optimaliz\u00e1ciu stafylokin\u00e1z s cie\u013eom vyvin\u00fa\u0165 \u00fa\u010dinnej\u0161ie trombolytick\u00e9 l\u00e1tky pre medic\u00ednske aplik\u00e1cie. 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