{"id":50521,"date":"2023-02-17T20:59:32","date_gmt":"2023-02-17T19:59:32","guid":{"rendered":"https:\/\/www.upjs.sk\/prirodovedecka-fakulta\/?post_type=cpt_aktuality&p=50521"},"modified":"2023-02-20T12:26:34","modified_gmt":"2023-02-20T11:26:34","slug":"microorganisms-a-key-to-understanding-hypericin-biosynthesis","status":"publish","type":"cpt_aktuality","link":"https:\/\/www.upjs.sk\/prirodovedecka-fakulta\/en\/actuality\/microorganisms-a-key-to-understanding-hypericin-biosynthesis\/","title":{"rendered":"Microorganisms: A Key to Understanding Hypericin Biosynthesis"},"content":{"rendered":"\n

The team of Department of Genetics, Institute of Biology and Ecology<\/strong>, Faculty of Science, P. J. \u0160af\u00e1rik University in Ko\u0161ice under the leadership of prof. RNDr. Eva \u010cell\u00e1rov\u00e1, DrSc<\/strong>. has been engaged in research of natural compounds with significant pharmacological and therapeutic potential for many years. These are mainly bioactive anthraquinones, primarily hypericin. Some, but not all representatives of the genus Hypericum<\/em> are the only producers of hypericin in the plant kingdom. The availability of hypericin and other bioactive substances on the world market is ensured essentially by Hypericum perforatum<\/em>.<\/p>\n\n\n\n

In addition to plants representing predominantly by the Hypericum<\/em> species, the anthraquinones including hypericin, and its putative intermediates emodin, emodin anthrone, skyrin and others are widespread in fungi including fungal plant-borne endophytes<\/strong>. Biosynthetic core genes and genes coding for regulatory elements are clustered in the fungal genomes and reveal fundamental aspects of their potential genetic and regulatory function at the genomic level. Understanding of genetic and epigenetic background of the anthraquinone biosynthetic gene clusters and way of their activation in fungal endophytes would help not only understand their pathways in plants, especially Hypericum<\/em> spp. as the essential producers of hypericin in the plant kingdom, but also favour them as promising heterologous\/homologous system for prospective biotechnological production of hypericin and other desirable anthraquinones.<\/p>\n\n\n\n

The team of Department of Genetics, Institute of Biology and Ecology<\/strong>, Faculty of Science, P. J. \u0160af\u00e1rik University in Ko\u0161ice under the leadership of prof. RNDr. Eva \u010cell\u00e1rov\u00e1, DrSc<\/strong>. has been engaged in research of natural compounds with significant pharmacological and therapeutic potential for many years. These are mainly bioactive anthraquinones, primarily hypericin. Some, but not all representatives of the genus Hypericum<\/em> are the only producers of hypericin in the plant kingdom. The availability of hypericin and other bioactive substances on the world market is ensured essentially by Hypericum perforatum<\/em>.<\/p>\n\n\n\n

In addition to plants representing predominantly by the Hypericum<\/em> species, the anthraquinones including hypericin, and its putative intermediates emodin, emodin anthrone, skyrin and others are widespread in fungi including fungal plant-borne endophytes<\/strong>. Biosynthetic core genes and genes coding for regulatory elements are clustered in the fungal genomes and reveal fundamental aspects of their potential genetic and regulatory function at the genomic level. Understanding of genetic and epigenetic background of the anthraquinone biosynthetic gene clusters and way of their activation in fungal endophytes would help not only understand their pathways in plants, especially Hypericum<\/em> spp. as the essential producers of hypericin in the plant kingdom, but also favour them as promising heterologous\/homologous system for prospective biotechnological production of hypericin and other desirable anthraquinones.<\/p>\n\n\n