{"id":76853,"date":"2025-03-14T15:23:29","date_gmt":"2025-03-14T14:23:35","guid":{"rendered":"https:\/\/www.upjs.sk\/prirodovedecka-fakulta\/pracoviska\/ustavy-pf\/ubev\/vv\/biochemia-a-molekularna-biologia-rastlinneho-metabolizmu-2\/"},"modified":"2025-05-22T14:15:35","modified_gmt":"2025-05-22T13:15:35","slug":"experimentalna-onkologia","status":"publish","type":"cpt_pracoviska","link":"https:\/\/www.upjs.sk\/prirodovedecka-fakulta\/pracoviska\/ustavy-pf\/ubev\/vv\/experimentalna-onkologia\/","title":{"rendered":"Experiment\u00e1lna onkol\u00f3gia"},"content":{"rendered":"<style>.kb-image76853_32ecac-e2 .kb-image-has-overlay:after{opacity:0.3;border-top-left-radius:5px;border-top-right-radius:5px;border-bottom-right-radius:5px;border-bottom-left-radius:5px;}.kb-image76853_32ecac-e2 img.kb-img, .kb-image76853_32ecac-e2 .kb-img img{border-top-left-radius:5px;border-top-right-radius:5px;border-bottom-right-radius:5px;border-bottom-left-radius:5px;}<\/style>\n<figure class=\"wp-block-kadence-image kb-image76853_32ecac-e2 size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1170\" height=\"200\" src=\"https:\/\/www.upjs.sk\/app\/uploads\/sites\/10\/2025\/03\/banner-il-vyskum-UBEV-onkologia.png\" alt=\"\" class=\"kb-img wp-image-76854\" srcset=\"https:\/\/www.upjs.sk\/app\/uploads\/sites\/10\/2025\/03\/banner-il-vyskum-UBEV-onkologia.png 1170w, https:\/\/www.upjs.sk\/app\/uploads\/sites\/10\/2025\/03\/banner-il-vyskum-UBEV-onkologia-300x51.png 300w, https:\/\/www.upjs.sk\/app\/uploads\/sites\/10\/2025\/03\/banner-il-vyskum-UBEV-onkologia-1024x175.png 1024w, https:\/\/www.upjs.sk\/app\/uploads\/sites\/10\/2025\/03\/banner-il-vyskum-UBEV-onkologia-768x131.png 768w\" sizes=\"auto, (max-width: 1170px) 100vw, 1170px\" \/><\/figure>\n\n\n<style>.kadence-column76853_e47129-ac > .kt-inside-inner-col{padding-top:var(--global-kb-spacing-xs, 1rem);padding-right:var(--global-kb-spacing-xs, 1rem);padding-left:var(--global-kb-spacing-xs, 1rem);}.kadence-column76853_e47129-ac > .kt-inside-inner-col,.kadence-column76853_e47129-ac > .kt-inside-inner-col:before{border-top-left-radius:5px;border-top-right-radius:5px;border-bottom-right-radius:5px;border-bottom-left-radius:5px;}.kadence-column76853_e47129-ac > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column76853_e47129-ac > .kt-inside-inner-col{flex-direction:column;}.kadence-column76853_e47129-ac > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column76853_e47129-ac > .kt-inside-inner-col{background-color:#F4F4F4;}.kadence-column76853_e47129-ac > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column76853_e47129-ac{position:relative;}@media all and (max-width: 1024px){.kadence-column76853_e47129-ac > .kt-inside-inner-col{flex-direction:column;}}@media all and (max-width: 767px){.kadence-column76853_e47129-ac > .kt-inside-inner-col{flex-direction:column;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column76853_e47129-ac\"><div class=\"kt-inside-inner-col\">\n<p class=\"has-text-align-justify\">V\u00fdskum je zameran\u00fd preva\u017ene na sk\u00famanie vplyvu pr\u00edrodn\u00fdch l\u00e1tok, ak\u00fdmi s\u00fa hyperic\u00edn, hyperfor\u00edn, skyr\u00edn a r\u00f4znych typov syntetick\u00fdch l\u00e1tok na procesy angiogen\u00e9zy, epitelovo-mezench\u00fdmovej tranz\u00edcie a vlastnosti n\u00e1dorov\u00fdch buniek v\u0161eobecne, ako aj na v\u00fdskyt tzv. kme\u0148ov\u00fdch buniek n\u00e1dorov, a to v podmienkach <em>in vitro<\/em>, <em>ex ovo <\/em>a&nbsp;<em>in vivo<\/em>. V r\u00e1mci v\u00fdskumu sa zaober\u00e1me aj \u00falohou sign\u00e1lnych molek\u00fal a transkrip\u010dn\u00fdch faktorov v regul\u00e1cii expresie a aktivity ABC transportn\u00fdch prote\u00ednov a mo\u017enos\u0165ami vyu\u017eitia r\u00f4znych typov nano\u0161trukt\u00far v modul\u00e1cii hydrof\u00f3bneho charakteru a terapeutick\u00e9ho potenci\u00e1lu vybran\u00fdch sekund\u00e1rnych metabolitov pr\u00edrodn\u00e9ho p\u00f4vodu.<\/p>\n<\/div><\/div>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<style>.kadence-column76853_000229-ac > .kt-inside-inner-col{padding-top:var(--global-kb-spacing-xs, 1rem);padding-right:var(--global-kb-spacing-xs, 1rem);padding-left:var(--global-kb-spacing-xs, 1rem);}.kadence-column76853_000229-ac > .kt-inside-inner-col,.kadence-column76853_000229-ac > .kt-inside-inner-col:before{border-top-left-radius:5px;border-top-right-radius:5px;border-bottom-right-radius:5px;border-bottom-left-radius:5px;}.kadence-column76853_000229-ac > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column76853_000229-ac > .kt-inside-inner-col{flex-direction:column;}.kadence-column76853_000229-ac > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column76853_000229-ac > .kt-inside-inner-col{background-color:#F4F4F4;}.kadence-column76853_000229-ac > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column76853_000229-ac{position:relative;}@media all and (max-width: 1024px){.kadence-column76853_000229-ac > .kt-inside-inner-col{flex-direction:column;}}@media all and (max-width: 767px){.kadence-column76853_000229-ac > .kt-inside-inner-col{flex-direction:column;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column76853_000229-ac\"><div class=\"kt-inside-inner-col\">\n<p class=\"has-text-align-justify\"><strong><mark style=\"background-color: rgba(0, 0, 0, 0);\" class=\"has-inline-color has-prirodovedecka-f-color\">AKTU\u00c1LNE RIE\u0160EN\u00c9 PROJEKTY:<\/mark><\/strong><br>VEGA 1\/0003\/23 Zmeny regul\u00e1cie expresie a aktivity transportn\u00e9ho prote\u00ednu BCRP vo vz\u0165ahu k proangiog\u00e9nnemu a metastatick\u00e9mu potenci\u00e1lu n\u00e1dorov\u00fdch buniek<\/p>\n\n\n\n<p class=\"has-text-align-justify\">VVGS-2023-3024 Hyperfor\u00edn \u2013 potenci\u00e1le lie\u010divo kolorekt\u00e1lnych n\u00e1dorov alebo l\u00e1tka umoc\u0148uj\u00faca ich mal\u00edgny potenci\u00e1l? <\/p>\n\n\n\n<p class=\"has-text-align-justify\">VVGS-2023-2911 Vplyv interakcie transkrip\u010dn\u00e9ho faktora Snail a prote\u00ednov rodiny ERM na regul\u00e1ciu efluxnej aktivity ABC transportn\u00fdch prote\u00ednov<\/p>\n<\/div><\/div>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<style>.kadence-column76853_eb2ccd-23 > .kt-inside-inner-col{padding-top:var(--global-kb-spacing-xs, 1rem);padding-right:var(--global-kb-spacing-xs, 1rem);padding-left:var(--global-kb-spacing-xs, 1rem);}.kadence-column76853_eb2ccd-23 > .kt-inside-inner-col,.kadence-column76853_eb2ccd-23 > .kt-inside-inner-col:before{border-top-left-radius:5px;border-top-right-radius:5px;border-bottom-right-radius:5px;border-bottom-left-radius:5px;}.kadence-column76853_eb2ccd-23 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column76853_eb2ccd-23 > .kt-inside-inner-col{flex-direction:column;}.kadence-column76853_eb2ccd-23 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column76853_eb2ccd-23 > .kt-inside-inner-col{background-color:#F4F4F4;}.kadence-column76853_eb2ccd-23 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column76853_eb2ccd-23{position:relative;}@media all and (max-width: 1024px){.kadence-column76853_eb2ccd-23 > .kt-inside-inner-col{flex-direction:column;}}@media all and (max-width: 767px){.kadence-column76853_eb2ccd-23 > .kt-inside-inner-col{flex-direction:column;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column76853_eb2ccd-23\"><div class=\"kt-inside-inner-col\"><style>.kb-row-layout-id76853_a62254-42 > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id76853_a62254-42 > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id76853_a62254-42 > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);grid-template-columns:minmax(0, calc(40% - ((var(--global-kb-gap-md, 2rem) * 1 )\/2)))minmax(0, calc(60% - ((var(--global-kb-gap-md, 2rem) * 1 )\/2)));}.kb-row-layout-id76853_a62254-42 > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id76853_a62254-42 > .kt-row-column-wrap{grid-template-columns:repeat(2, minmax(0, 1fr));}}@media all and (max-width: 767px){.kb-row-layout-id76853_a62254-42 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id76853_a62254-42 alignnone wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-2-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top\">\n<style>.kadence-column76853_ae948a-c2 > .kt-inside-inner-col{display:flex;}.kadence-column76853_ae948a-c2 > .kt-inside-inner-col,.kadence-column76853_ae948a-c2 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column76853_ae948a-c2 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column76853_ae948a-c2 > .kt-inside-inner-col{flex-direction:column;justify-content:center;align-items:center;}.kadence-column76853_ae948a-c2 > .kt-inside-inner-col > .kb-image-is-ratio-size{align-self:stretch;}.kadence-column76853_ae948a-c2 > .kt-inside-inner-col > .wp-block-kadence-advancedgallery{align-self:stretch;}.kadence-column76853_ae948a-c2 > .kt-inside-inner-col > .aligncenter{width:100%;}.kt-row-column-wrap > .kadence-column76853_ae948a-c2{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column76853_ae948a-c2{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column76853_ae948a-c2 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column76853_ae948a-c2 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column76853_ae948a-c2{position:relative;}@media all and (max-width: 1024px){.kt-row-column-wrap > .kadence-column76853_ae948a-c2{align-self:center;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column76853_ae948a-c2{align-self:auto;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column76853_ae948a-c2 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 1024px){.kadence-column76853_ae948a-c2 > .kt-inside-inner-col{flex-direction:column;align-items:center;}}@media all and (max-width: 767px){.kt-row-column-wrap > .kadence-column76853_ae948a-c2{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column76853_ae948a-c2{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column76853_ae948a-c2 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column76853_ae948a-c2 > .kt-inside-inner-col{flex-direction:column;align-items:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column76853_ae948a-c2\"><div class=\"kt-inside-inner-col\">\n<p><strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-prirodovedecka-f-color\">\u010cLENOVIA T\u00cdMU:<\/mark><\/strong><br><a href=\"https:\/\/www.upjs.sk\/PF\/zamestnanec\/peter.fedorocko\/\">prof. RNDr. Peter Fedoro\u010dko, CSc.<\/a><br><a href=\"https:\/\/www.upjs.sk\/PF\/zamestnanec\/monika.kassayova\/\">doc. RNDr. Monika Kassayov\u00e1, CSc.<\/a><br><a href=\"https:\/\/www.upjs.sk\/PF\/zamestnanec\/bianka.bojkova\/\">doc. RNDr. Bianka Bojkov\u00e1, PhD.<\/a><br><a href=\"https:\/\/www.upjs.sk\/PF\/zamestnanec\/rastislav.jendzelovsky\/\">doc. RNDr. Rastislav Jend\u017eelovsk\u00fd, PhD.<\/a><br><a href=\"https:\/\/www.upjs.sk\/PF\/zamestnanec\/zuzana.jendzelovska\/\">RNDr. Zuzana Jend\u017eelovsk\u00e1, PhD.<\/a><br><a href=\"https:\/\/www.upjs.sk\/PF\/zamestnanec\/jana.vargova\/\">RNDr. Jana Vargov\u00e1, PhD.<\/a><br><a href=\"https:\/\/www.upjs.sk\/PF\/zamestnanec\/martin.panigaj\/\">Mgr. Martin Panigaj, PhD.<\/a><br><a href=\"https:\/\/www.upjs.sk\/PF\/zamestnanec\/martin.majernik\/\">RNDr. Mgr. Martin Majern\u00edk, PhD.<\/a><br><a href=\"https:\/\/www.upjs.sk\/PF\/zamestnanec\/marian.babincak\/\">RNDr. Mari\u00e1n Babin\u010d\u00e1k, PhD.<\/a><br><a href=\"https:\/\/www.upjs.sk\/PF\/zamestnanec\/viktoria.decmanova\/\">RNDr. Vikt\u00f3ria De\u010dmanov\u00e1, PhD.<\/a><br><br><strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-prirodovedecka-f-color\">DOKTORANDI:<\/mark><\/strong><br><a href=\"https:\/\/www.upjs.sk\/PF\/zamestnanec\/michaela.romanovova\/\">RNDr. Michaela Romanovov\u00e1<\/a><br><a href=\"https:\/\/www.upjs.sk\/PF\/zamestnanec\/ivana.barcakova\/\">RNDr. Ivana Bar\u010d\u00e1kov\u00e1<\/a><br><a href=\"https:\/\/www.upjs.sk\/PF\/zamestnanec\/gabriela.blaskova\/\">Mgr. Gabriela Bla\u0161kov\u00e1<\/a><br><a href=\"https:\/\/www.upjs.sk\/PF\/zamestnanec\/lucia.hudakova\/\">Mgr. Lucia Hud\u00e1kov\u00e1<\/a><br><br><strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-prirodovedecka-f-color\">ODBORN\u00cd ZAMESTNANCI:<\/mark><\/strong><br><a href=\"https:\/\/www.upjs.sk\/PF\/zamestnanec\/viera.balazova\/\">Viera Bala\u017eov\u00e1<\/a><\/p>\n<\/div><\/div>\n\n\n<style>.kadence-column76853_e6cb50-13 > .kt-inside-inner-col{display:flex;}.kadence-column76853_e6cb50-13 > .kt-inside-inner-col,.kadence-column76853_e6cb50-13 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column76853_e6cb50-13 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column76853_e6cb50-13 > .kt-inside-inner-col{flex-direction:column;justify-content:center;align-items:center;}.kadence-column76853_e6cb50-13 > .kt-inside-inner-col > .kb-image-is-ratio-size{align-self:stretch;}.kadence-column76853_e6cb50-13 > .kt-inside-inner-col > .wp-block-kadence-advancedgallery{align-self:stretch;}.kadence-column76853_e6cb50-13 > .kt-inside-inner-col > .aligncenter{width:100%;}.kt-row-column-wrap > .kadence-column76853_e6cb50-13{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column76853_e6cb50-13{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column76853_e6cb50-13 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column76853_e6cb50-13 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column76853_e6cb50-13{position:relative;}@media all and (max-width: 1024px){.kt-row-column-wrap > .kadence-column76853_e6cb50-13{align-self:center;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column76853_e6cb50-13{align-self:auto;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column76853_e6cb50-13 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 1024px){.kadence-column76853_e6cb50-13 > .kt-inside-inner-col{flex-direction:column;align-items:center;}}@media all and (max-width: 767px){.kt-row-column-wrap > .kadence-column76853_e6cb50-13{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column76853_e6cb50-13{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column76853_e6cb50-13 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column76853_e6cb50-13 > .kt-inside-inner-col{flex-direction:column;align-items:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column76853_e6cb50-13\"><div class=\"kt-inside-inner-col\"><style>.kb-image76853_7a01e5-df.kb-image-is-ratio-size, .kb-image76853_7a01e5-df .kb-image-is-ratio-size{max-width:476px;width:100%;}.wp-block-kadence-column > .kt-inside-inner-col > .kb-image76853_7a01e5-df.kb-image-is-ratio-size, .wp-block-kadence-column > .kt-inside-inner-col > .kb-image76853_7a01e5-df .kb-image-is-ratio-size{align-self:unset;}.kb-image76853_7a01e5-df{max-width:476px;}.image-is-svg.kb-image76853_7a01e5-df{-webkit-flex:0 1 100%;flex:0 1 100%;}.image-is-svg.kb-image76853_7a01e5-df img{width:100%;}.kb-image76853_7a01e5-df .kb-image-has-overlay:after{opacity:0.3;border-top-left-radius:5px;border-top-right-radius:5px;border-bottom-right-radius:5px;border-bottom-left-radius:5px;}.kb-image76853_7a01e5-df img.kb-img, .kb-image76853_7a01e5-df .kb-img img{border-top-left-radius:5px;border-top-right-radius:5px;border-bottom-right-radius:5px;border-bottom-left-radius:5px;}<\/style>\n<figure class=\"wp-block-kadence-image kb-image76853_7a01e5-df size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"900\" height=\"720\" src=\"https:\/\/www.upjs.sk\/app\/uploads\/sites\/10\/2025\/03\/UBEV-vyskum-Experimentalna-onkologia.jpg\" alt=\"\" class=\"kb-img wp-image-79110\" srcset=\"https:\/\/www.upjs.sk\/app\/uploads\/sites\/10\/2025\/03\/UBEV-vyskum-Experimentalna-onkologia.jpg 900w, https:\/\/www.upjs.sk\/app\/uploads\/sites\/10\/2025\/03\/UBEV-vyskum-Experimentalna-onkologia-300x240.jpg 300w, https:\/\/www.upjs.sk\/app\/uploads\/sites\/10\/2025\/03\/UBEV-vyskum-Experimentalna-onkologia-768x614.jpg 768w\" sizes=\"auto, (max-width: 900px) 100vw, 900px\" \/><\/figure>\n<\/div><\/div>\n\n<\/div><\/div><\/div><\/div>\n\n\n<style>.wp-block-kadence-column.kb-section-dir-horizontal > .kt-inside-inner-col > .kt-info-box76853_33bccb-fc .kt-blocks-info-box-link-wrap{max-width:unset;}.kt-info-box76853_33bccb-fc .kt-blocks-info-box-link-wrap{border-top:0px solid var(--global-palette7, #eeeeee);border-right:0px solid var(--global-palette7, #eeeeee);border-bottom:0px solid var(--global-palette7, #eeeeee);border-left:0px 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