{"id":76859,"date":"2025-03-14T15:39:29","date_gmt":"2025-03-14T14:39:48","guid":{"rendered":"https:\/\/www.upjs.sk\/prirodovedecka-fakulta\/pracoviska\/ustavy-pf\/ubev\/vv\/biochemia-a-molekularna-biologia-rastlinneho-metabolizmu-2\/"},"modified":"2025-04-03T15:14:26","modified_gmt":"2025-04-03T14:14:26","slug":"crev-mikrobiot-extraintest-ochorenia","status":"publish","type":"cpt_pracoviska","link":"https:\/\/www.upjs.sk\/prirodovedecka-fakulta\/pracoviska\/ustavy-pf\/ubev\/vv\/crev-mikrobiot-extraintest-ochorenia\/","title":{"rendered":"\u00daloha \u010drevnej mikrobioty v patogen\u00e9ze GIT a extraintestin\u00e1lnych ochoren\u00ed"},"content":{"rendered":"<style>.kb-image76859_2cac1d-d6 .kb-image-has-overlay:after{opacity:0.3;border-top-left-radius:5px;border-top-right-radius:5px;border-bottom-right-radius:5px;border-bottom-left-radius:5px;}.kb-image76859_2cac1d-d6 img.kb-img, .kb-image76859_2cac1d-d6 .kb-img img{border-top-left-radius:5px;border-top-right-radius:5px;border-bottom-right-radius:5px;border-bottom-left-radius:5px;}<\/style>\n<figure class=\"wp-block-kadence-image kb-image76859_2cac1d-d6 size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1170\" height=\"200\" src=\"https:\/\/www.upjs.sk\/app\/uploads\/sites\/10\/2025\/03\/banner-il-vyskum-UBEV-mikrobiot.png\" alt=\"\" class=\"kb-img wp-image-76860\" srcset=\"https:\/\/www.upjs.sk\/app\/uploads\/sites\/10\/2025\/03\/banner-il-vyskum-UBEV-mikrobiot.png 1170w, https:\/\/www.upjs.sk\/app\/uploads\/sites\/10\/2025\/03\/banner-il-vyskum-UBEV-mikrobiot-300x51.png 300w, https:\/\/www.upjs.sk\/app\/uploads\/sites\/10\/2025\/03\/banner-il-vyskum-UBEV-mikrobiot-1024x175.png 1024w, https:\/\/www.upjs.sk\/app\/uploads\/sites\/10\/2025\/03\/banner-il-vyskum-UBEV-mikrobiot-768x131.png 768w\" sizes=\"auto, (max-width: 1170px) 100vw, 1170px\" \/><\/figure>\n\n\n<style>.kadence-column76859_41bb76-db > .kt-inside-inner-col{padding-top:var(--global-kb-spacing-xs, 1rem);padding-right:var(--global-kb-spacing-xs, 1rem);padding-left:var(--global-kb-spacing-xs, 1rem);}.kadence-column76859_41bb76-db > .kt-inside-inner-col,.kadence-column76859_41bb76-db > .kt-inside-inner-col:before{border-top-left-radius:5px;border-top-right-radius:5px;border-bottom-right-radius:5px;border-bottom-left-radius:5px;}.kadence-column76859_41bb76-db > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column76859_41bb76-db > .kt-inside-inner-col{flex-direction:column;}.kadence-column76859_41bb76-db > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column76859_41bb76-db > .kt-inside-inner-col{background-color:#F4F4F4;}.kadence-column76859_41bb76-db > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column76859_41bb76-db{position:relative;}@media all and (max-width: 1024px){.kadence-column76859_41bb76-db > .kt-inside-inner-col{flex-direction:column;}}@media all and (max-width: 767px){.kadence-column76859_41bb76-db > .kt-inside-inner-col{flex-direction:column;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column76859_41bb76-db\"><div class=\"kt-inside-inner-col\">\n<p class=\"has-text-align-justify\">V\u00fdskum je zameran\u00fd na komplexn\u00e9 \u0161t\u00fadium interakci\u00ed medzi \u010drevnou mikrobiotou a imunitn\u00fdm syst\u00e9mom v s\u00favislosti s gastrointestin\u00e1lnymi a extraintestin\u00e1lnymi ochoreniami, s osobitn\u00fdm d\u00f4razom na poruchy autistick\u00e9ho spektra (PAS). Na\u0161\u00edm hlavn\u00fdm cie\u013eom je identifikova\u0165 \u0161pecifick\u00e9 mikrobi\u00e1lne a metabolick\u00e9 profily podie\u013eaj\u00face sa na patogen\u00e9ze t\u00fdchto ochoren\u00ed a presk\u00fama\u0165 mo\u017enosti cielenej modul\u00e1cie \u010drevn\u00e9ho mikrobi\u00f3mu ako s\u00fa\u010das\u0165 inovat\u00edvnych terapeutick\u00fdch strat\u00e9gi\u00ed. Hlavn\u00e9 oblasti v\u00fdskumu:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u010crevn\u00e1 dysbi\u00f3za a patogen\u00e9za ochoren\u00ed:<\/strong> Anal\u00fdza zmien v mikrobi\u00e1lnom zlo\u017een\u00ed a funk\u010dnom metabolizme pri z\u00e1palov\u00fdch ochoreniach \u010driev (IBD) a neurov\u00fdvinov\u00fdch poruch\u00e1ch vr\u00e1tane por\u00fach autistick\u00e9ho spektra (PAS),<\/li>\n\n\n\n<li><strong>Vplyv mikrobi\u00e1lnych metabolitov na os \u010drevo-mozog:<\/strong> Sk\u00famanie kr\u00e1tkore\u0165azcov\u00fdch mastn\u00fdch kysel\u00edn (SCFA), tryptof\u00e1nov\u00e9ho metabolizmu a ich \u00falohy v neuroz\u00e1pale a imunitnej odpovedi,<\/li>\n\n\n\n<li><strong>Mikrobi\u00e1lne a imunomodula\u010dn\u00e9 terapie:<\/strong> V\u00fdvoj strat\u00e9gi\u00ed na ovplyvnenie \u010drevn\u00e9ho mikrobi\u00f3mu pomocou fermentovan\u00fdch potrav\u00edn, probiot\u00edk, prebiot\u00edk, synbiot\u00edk a fek\u00e1lnej mikrobi\u00e1lnej transplant\u00e1cie (FMT).<\/li>\n<\/ul>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-text-align-justify\">Na\u0161a pr\u00e1ca zah\u0155\u0148a kombin\u00e1ciu metagenomick\u00fdch, metabolomick\u00fdch a imunologick\u00fdch anal\u00fdz s vyu\u017eit\u00edm preklinick\u00fdch modelov a klinick\u00fdch vzoriek. Dlhodob\u00fdm cie\u013eom je prispie\u0165 k v\u00fdvoju personalizovan\u00fdch terapeutick\u00fdch pr\u00edstupov, ktor\u00e9 bud\u00fa cielene ovplyv\u0148ova\u0165 \u010drevn\u00fa mikrobiotu a jej vplyv na celkov\u00e9 zdravie hostite\u013ea.<\/p>\n<\/div><\/div>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<style>.kadence-column76859_08f266-62 > .kt-inside-inner-col{padding-top:var(--global-kb-spacing-xs, 1rem);padding-right:var(--global-kb-spacing-xs, 1rem);padding-left:var(--global-kb-spacing-xs, 1rem);}.kadence-column76859_08f266-62 > .kt-inside-inner-col,.kadence-column76859_08f266-62 > .kt-inside-inner-col:before{border-top-left-radius:5px;border-top-right-radius:5px;border-bottom-right-radius:5px;border-bottom-left-radius:5px;}.kadence-column76859_08f266-62 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column76859_08f266-62 > .kt-inside-inner-col{flex-direction:column;}.kadence-column76859_08f266-62 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column76859_08f266-62 > .kt-inside-inner-col{background-color:#F4F4F4;}.kadence-column76859_08f266-62 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column76859_08f266-62{position:relative;}@media all and (max-width: 1024px){.kadence-column76859_08f266-62 > .kt-inside-inner-col{flex-direction:column;}}@media all and (max-width: 767px){.kadence-column76859_08f266-62 > .kt-inside-inner-col{flex-direction:column;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column76859_08f266-62\"><div class=\"kt-inside-inner-col\"><style>.kb-row-layout-id76859_674046-f7 > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id76859_674046-f7 > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id76859_674046-f7 > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);grid-template-columns:minmax(0, calc(40% - ((var(--global-kb-gap-md, 2rem) * 1 )\/2)))minmax(0, calc(60% - ((var(--global-kb-gap-md, 2rem) * 1 )\/2)));}.kb-row-layout-id76859_674046-f7 > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id76859_674046-f7 > .kt-row-column-wrap{grid-template-columns:repeat(2, minmax(0, 1fr));}}@media all and (max-width: 767px){.kb-row-layout-id76859_674046-f7 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id76859_674046-f7 alignnone wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-2-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top\">\n<style>.kadence-column76859_7f23d0-a0 > .kt-inside-inner-col,.kadence-column76859_7f23d0-a0 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column76859_7f23d0-a0 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column76859_7f23d0-a0 > .kt-inside-inner-col{flex-direction:column;}.kadence-column76859_7f23d0-a0 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column76859_7f23d0-a0 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column76859_7f23d0-a0{position:relative;}@media all and (max-width: 1024px){.kadence-column76859_7f23d0-a0 > .kt-inside-inner-col{flex-direction:column;}}@media all and (max-width: 767px){.kadence-column76859_7f23d0-a0 > .kt-inside-inner-col{flex-direction:column;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column76859_7f23d0-a0\"><div class=\"kt-inside-inner-col\">\n<p><strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-prirodovedecka-f-color\">\u010cLENOVIA T\u00cdMU:<\/mark><\/strong><br><a href=\"https:\/\/www.upjs.sk\/PF\/zamestnanec\/vlasta.demeckova\/\">RNDr. Vlasta Deme\u010dkov\u00e1, PhD. univerzitn\u00e1 docentka<\/a><\/p>\n\n\n\n<p><strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-prirodovedecka-f-color\">DOKTORANDI:<\/mark><\/strong><br><a href=\"https:\/\/www.upjs.sk\/PF\/zamestnanec\/maria.rynikova\/\">RNDr. M\u00e1ria Ryn\u00edkov\u00e1<\/a><\/p>\n<\/div><\/div>\n\n\n<style>.kadence-column76859_232ff3-5c > .kt-inside-inner-col,.kadence-column76859_232ff3-5c > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column76859_232ff3-5c > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column76859_232ff3-5c > .kt-inside-inner-col{flex-direction:column;}.kadence-column76859_232ff3-5c > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column76859_232ff3-5c > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column76859_232ff3-5c{position:relative;}@media all and (max-width: 1024px){.kadence-column76859_232ff3-5c > .kt-inside-inner-col{flex-direction:column;}}@media all and (max-width: 767px){.kadence-column76859_232ff3-5c > .kt-inside-inner-col{flex-direction:column;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column76859_232ff3-5c\"><div class=\"kt-inside-inner-col\">\n<p class=\"has-text-align-justify\"><strong><mark class=\"has-inline-color has-prirodovedecka-f-color\" style=\"background-color: rgba(0, 0, 0, 0);\">AKTU\u00c1LNE RIE\u0160EN\u00c9 PROJEKTY:<\/mark><\/strong><br>VEGA 1\/0389\/25 Optimaliz\u00e1cia terapeutickej \u00fa\u010dinnosti FMT pomocou natur\u00e1lneho adit\u00edva v lie\u010dbe ne\u0161pecifick\u00fdch z\u00e1palov \u010driev indukovan\u00fdch na PGF anim\u00e1lnom modeli ak\u00fatnej UC<\/p>\n\n\n\n<p class=\"has-text-align-justify\">APVV-20-0114 Pohlavne-\u0161pecifick\u00fd mikrobi\u00f3m a g\u00e9nov\u00e9 interakcie v patogen\u00e9ze behavior\u00e1lnych a gastrointestin\u00e1lnych sympt\u00f3mov v anim\u00e1lnom modeli por\u00fach autistick\u00e9ho spektra<\/p>\n\n\n\n<p class=\"has-text-align-justify\">APVV-23-0031 Transplant\u00e1cia fek\u00e1lnej mikrobioty a jej potenci\u00e1lne vyu\u017eitie pri ne\u0161pecifick\u00fdch z\u00e1palov\u00fdch ochoreniach \u010driev v hum\u00e1nnej a veterin\u00e1rnej medic\u00edne<\/p>\n<\/div><\/div>\n\n<\/div><\/div><\/div><\/div>\n","protected":false},"author":1,"featured_media":0,"parent":20563,"menu_order":10,"template":"","meta":{"_acf_changed":false,"_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}"},"categories":[],"tags":[],"tax_aktuality":[],"class_list":["post-76859","cpt_pracoviska","type-cpt_pracoviska","status-publish","hentry"],"acf":{"acf_link_na_externy_obsah":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.3 - 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