2021
Babinčák M., Jendželovský R., Košuth J., Majerník M., Vargová J., Mikulášek K., Zdráhal Z., Fedoročko P. Death Receptor 5 (TNFRSF10B) Is Upregulated and TRAIL Resistance Is Reversed in Hypoxia and Normoxia in Colorectal Cancer Cell Lines after Treatment with Skyrin, the Active Metabolite of Hypericum spp. Cancers, 2021, 13, 1646. DOI: 10.3390/cancers13071646
Hudáčová M., Hamuľaková S., Konkoľová E., Jendželovský R., Vargová J., Ševc J., Fedoročko P., Soukup O., Janočková J., Ihnatova V., Kučera T., Bzonek P., Novakova N., Jun D., Junova L., Korábečný J., Kuča K., Kožurková M. Synthesis of new biscoumarin derivatives, in vitro cholinesterase inhibition, molecular modelling and antiproliferative effect in A549 human lung carcinoma cells. International Journal of Molecular Sciences, 2021, 22, 3830. DOI: 10.3390/ijms22083830
Konkoľová E., Hudáčová M., Hamuľaková S., Jendželovský R., Vargová J., Ševc J., Fedoročko P., Kožurková M. Tacrine-Coumarin Derivatives as Topoisomerase Inhibitors with Antitumor Effects on A549 Human Lung Carcinoma Cancer Cell Lines. Molecules, 2021, 26, 1133. DOI: 10.3390/molecules26041133
Panigaj M, Dobrovolskaia MA, and Afonin KA. 2021: an immunotherapy odyssey and the rise of nucleic acid nanotechnology. Nanomedicine, 2021. DOI: 10.2217/nnm-2021-0097
2020
Chandler M, Panigaj M, Johnson MB, and Afonin KA. Innate immune responses triggered by nucleic acids inspire the design of immunomodulatory nucleic acid nanoparticles (NANPs). Current Opinion in Biotechnology, 2020, 63: 8-15. DOI: 10.1016/j.copbio.2019.10.011
Chandler M, Panigaj M, Rolband LA, Afonin KA. Challenges to optimizing RNA nanostructures for large scale production and controlled therapeutic properties. Nanomedicine (Lond), 2020, 15(13):1331-40. DOI: 10.2217/nnm-2020-0034
Tonelli Gombalová, Z. , Košuth, J. , Alexovič Matiašová, A., Zrubáková , J., Žežula, I., Giallongo, T., Di Giulio, A.M., Carelli, S., Tomašková, L., Daxnerová, Z., Ševc, J. Majority of cerebrospinal fluid-contacting neurons in the spinal cord of C57Bl/6N mice is present in ectopic position unlike in other studied experimental mice strains and mammalian species. Journal of Comparative Neurology, 2020, 528(15):2523-2550. DOI: 10.1002/cne.24909
Košuth, J., Farkašovská, M., Mochnacký, F., Daxnerová, Z., Ševc, J. Selection of reliable reference genes for analysis of gene expression in spinal cord during rat postnatal development and after injury. Brain Sciences, 2020, 10(1):6. DOI: 10.3390/brainsci10010006
Majerník M., Jendželovský R., Fedoročko P. Potentiality, Limitations, and Consequences of Different Experimental Models to Improve Photodynamic Therapy for Cancer Treatment in Relation to Antiangiogenic Mechanism. Cancers, 2020, 12, 2118. DOI: 10.3390/cancers12082118
Macejová M., Sačková V., Hradická P., Jendželovský R., Demečková V., Fedoročko P. Combination of photoactive hypericin and Manumycin A exerts multiple anticancer effects on oxaliplatin-resistant colorectal cells. Toxicology in Vitro, 2020, 66, 104860. DOI: 10.1016/j.tiv.2020.104860
Suváková M., Majerník M., Jendželovský R., Hovan A., Bánó G., Fedoročko P., Antalík M. In vitro study of disodium cromoglicate as a novel effective hydrotrope solvent for hypericin utilisation in photodynamic therapy. Journal of Photochemistry & Photobiology, B: Biology, 2020, 206, 111855. DOI: 10.1016/j.jphotobiol.2020.111855
Pipová Kokošová N., Kisková T., Vilhanová K., Štafuriková A., Jendželovský R., Račeková E., Šmajda B. Melatonin mitigates hippocampal and cognitive impairments caused by prenatal irradiation. European Journal of Neuroscience, 2020, 52(6):3575-3594. DOI: 10.1111/ejn.14687
Nunhart P., Konkoľová E., Janovec L., Jendželovský R., Vargová J., Ševc J., Matejová M., Miltáková B., Fedoročko P., Kozurkova M. Fluorinated 3,6,9-trisubstituted acridine derivatives as DNA interacting agents and topoisomerase inhibitors with A549 antiproliferative activity. Bioorg. Chem., 2020, 94, 103393. DOI: 10.1016/j.bioorg.2019.103393
2019
Majerník M., Jendželovský R., Babinčák M., Košuth J., Ševc J., Tonelli Gombalová Z., Jendželovská Z., Buríková M., Fedoročko P. Novel Insights into the Effect of Hyperforin and Photodynamic Therapy with Hypericin on Chosen Angiogenic Factors in Colorectal Micro-Tumors Created on Chorioallantoic Membrane. International Journal of Molecular Sciences, 2019, 20(12): 3004. DOI: 10.3390/ijms20123004
Jendželovský R., Jendželovská Z., Kuchárová B., Fedoročko P. Breast cancer resistance protein is the enemy of hypericin accumulation and toxicity of hypericin-mediated photodynamic therapy. Biomedicine and Pharmacotherapy, 2019, 109, 2173-2181. DOI: 10.1016/j.biopha.2018.11.084
Kuchárová V., Kuchár J., Lüköová A., Jendželovský R., Majerník M., Fedoročko P., Vilková M., Radojević D. I., Čomić R. L., Potočňák I. Low-dimensional compounds containing bioactive ligands. Part XII: Synthesis, structures, spectra, in vitro antimicrobial and cytotoxic activities of zinc(II) complexes with halogenderivatives of quinoline-8-ol. Polyhedron, 2019, 170:447-457. DOI: 10.1016/j.poly.2019.05.064
Janockova J., Korabecny J., Plsikova J., Babkova K., Konkolova E., Kucerova D., Vargova J., Koval J., Jendzelovsky R., Fedorocko P., Kasparkova J., Brabec V., Rosocha J., Soukup O., Hamulakova S., Kuca K., Kozurkova M. In vitro investigating of anticancer activity of new 7-MEOTA-tacrine heterodimers. Journal of Enzyme Inhibition and Medicinal Chemistry, 2019, 34, 877-897. DOI: 10.1080/14756366.2019.1593159
Panigaj M, Johnson MB, Ke W, McMillan J, Goncharova EA, Chandler M, and Afonin KA. Aptamers as Modular Components of Therapeutic Nucleic Acid Nanotechnology, ACS Nano, 2019, 13(11): 12301-12321. DOI: 10.1021/acsnano.9b06522
Ke W, Hong E, Saito RF, Rangel MC, Wang J, Viard M, Richardson M, Khisamutdinov EF, Panigaj M, Dokholyan NV, Chammas R, Dobrovolskaia MA, Afonin KA. RNA-DNA fibers and polygons with controlled immunorecognition activate RNAi, FRET, and transcriptional regulation of NF-κB in human cells, Nucleic Acids Research, 2019, 47(3): 1350-1361. DOI: 10.1093/nar/gky1215
Vranova E, Kopcsayova D, Kosuth J, Colinas M. Mutant-Based Model of Two Independent Pathways for Carotenoid-Mediated Chloroplast Biogenesis in Arabidopsis Embryos. Frontiers in Plant Science, 2019, 10, clanok 1034, DOI: 10.3389/fpls.2019.01034
Feckova B, Kimakova P, Ilkovicova L, Szentpeteriova E, Macejova M, Kosuth J, Zulli A, Debeljak N, Hudler P, Jasek K. Methylation of the first exon in the erythropoietin receptor gene does not correlate with its mRNA and protein level in cancer cells. BMC Genetics, 2019, 20, clanok 1, DOI: 10.1186/s12863-018-0706-8
2018
Vargová J., Mikeš J., Jendželovský R., Mikešová L., Kuchárová B., Čulka Ľ., Fedr R., Remšík J., Souček K., Kozubík A., Fedoročko P.: Hypericin affects cancer side populations via competitive inhibition of BCRP. Biomedicine and Pharmacotherapy, 2018, 99: 511-522, 2018, DOI: 10.1016/j.biopha.2018.01.074
2017
Halaburková A., Jendželovský R., Kovaľ J., Herceg Z., Fedoročko P., Ghantous A.: Histone deacetylase inhibitors potentiate photodynamic therapy in colon cancer cells marked by chromatin-mediated epigenetic regulation of cdnk1a. Clinical Epigenetics, 2017, 9:62. DOI: 10.1186/s13148-017-0359-x
Alexovič Matiašová, A., Ševc, J., Tomori, Z., Gombalová, Z., Gedrová, Š., Daxnerová, Z. Quantitative analyses of cellularity and proliferative activity reveals the dynamics of the central canal lining during postnatal development of rat. Journal of Comparative Neurology, 2017, 525(3):3963-707. DOI: 10.1002/cne.24091
Halman JR, Satterwhite E, Roark B, Chandler M, Viard M, Ivanina A, Bindewald E, Kasprzak WK, Panigaj M, Bui MN, Lu JS, Miller J, Khisamutdinov EF, Shapiro BA, Dobrovolskaia MA, Afonin KA. Functionally-interdependent shape-switching nanoparticles with controllable properties, Nucleic Acids Res., 2017, 45(4):2210-2220. DOI: 10.1093/nar/gkx008
Salem O. M., Vilková M., Janočková J., Jendželovský R., Fedoročko P., Imrich J., Kožurková M. Synthesis, spectral characterization, DNA binding ability and anti-cancer screening of new acridine-based derivatives. Medicinal Chemistry Research, 2017, 26:2309–2321. DOI: 10.1007/s00044-017-1931-9
Solár P., Sačková V., Hrčková G., Demečková V., Kassayová M., Bojková B., Mudroňová D., Gancarčíková S., Jendželovský R., Fedoročko P. Antitumor effect of the combination of manumycin A and Immodin is associated with antiplatelet activity and increased granulocyte tumor infiltration in a 4T1 breast tumor model. Oncology Reports, 2017, 37: 368-378. DOI: 10.3892/or.2016.5265
2016
Gyurászová K., Mikeš J., Halaburková A., Jendželovský R., Fedoročko P. YM155, a small molecule inhibitor of survivin expression, sensitizes cancer cells to hypericin-mediated photodynamic therapy. Photochemical & Photobiological Sciences, 2016, 15:812-821. DOI: 10.1039/c5pp00438a
Kassayová M., Bobrov N., Strojný L., Orendáš P., Demečková V. Jendželovský R., Kubatka P., Kisková T., Kružliak P., Adamkov M., Bomba A., Fedoročko P. Anticancer and Immunomodulatory Effects of Lactobacillus plantarum LS/07, Inulin and Melatonin in NMU-induced Rat Model of Breast Cancer. Anticancer Res, 2016, 36:2719-2728. PMID: 27272781
Šemeláková M., Jendželovský R., Fedoročko P. Drug membrane transporters and CYP3A4 are affected by hypericin, hyperforin or aristoforin in colon adenocarcinoma cells. Biomedicine and Pharmacotherapy, 2016, 81:38-47. DOI: 10.1016/j.jphotobiol.2012.09.003
Salem O. M., Vilková M., Janočková J., Jendželovský R., Fedoročko P., Žilecká E., Kašpárková J., Brabec V., Imrich J., Kožurková M. New spiro tria(thia)zolidine-acridines as topoisomerase inhibitors, DNA binders and cytostatic compounds. International Journal of Biological Macromolecules, 2016, 86:690-700. DOI: 10.1016/j.ijbiomac.2016.02.018
Jendželovská Z., Jendželovský R., Kuchárová B., Fedoročko P.: Hypericin in the light and in the dark: Two sides of the same coin. Frontiers in Plant Science,2016, 7:560. DOI: 10.3389/fpls.2016.00560
Jendželovský R., Jendželovská Z., Hiľovská L., Kovaľ J., Mikeš J., Fedoročko P. Proadifen sensitizes resistant ovarian adenocarcinoma cells to cisplatin. Toxicology Letters, 2016, 243:56-66. DOI: 10.1016/j.toxlet.2015.12.002
2015
Ševc, J., Matiašová, A., Smoleková, I., Jendželovský, R., Mikeš, J., Tomášová, L., Kútna, V., Daxnerová, Z., Fedoročko, P. Peroral administration of 5-bromo-2 ́-deoxyuridine in drinking water is not reliable method for labeling of proliferating S-phase cells in rats. Journal of Pharmacological and Toxicological Methods, 2015, 74:33-39. DOI: 10.1016/j.vascn.2015.05.012
Macko J., Oriňak A., Oriňaková R., Muhmann Ch., Petruš O., Harvanová D., Vargová J., Jendželovský R., Radoňák J., Fedoročko P., Arlinghaus H. F. New nanostructured nickel-polymer nanohybrids with improved surface hydrophobicity and effect on the living cells adhesion. Applied Surface Science, 2015, 355:553-561. DOI: 10.1016/j.apsusc.2015.07.104
Hiľovská L., Jendželovský R., Jendželovská Z., Kovaľ J, Fedoročko P. Downregulation of BCRP and anti-apoptotic proteins by proadifen (SKF-525A) is responsible for the enhanced mitoxantrone accumulation and toxicity in mitoxantrone-resistant human promyelocytic leukemia cells. International Journal of Oncology, 2015, 47:1572-1584. DOI: 10.3892/ijo.2015.3116
Kuchárová B., Mikeš J., Jendželovský R., Vargová J., Mikešová L., Jendželovská Z., Kovaľ J., Fedoročko P. Potentiation of hypericin-mediated photodynamic therapy cytotoxicity by MK-886: Focus on ABC transporters, GDF-15 and redox status. Photodiagnosis and Photodynamic therapy, 2015, 12:490-503. DOI: 10.1016/j.pdpdt.2015.04.008
Janočková J. Plšíková J., Kašpárková J., Brabec V., Jendželovský R., Mikeš J., Kovaľ J., Hamuľáková S., Fedoročko P., Kuča K., Kožurková M. Inhibition of DNA topoisomerases I and II and growth inhibition of HL-60 cells by novel acridine-based compounds. European Journal of Pharmaceutical Sciences, 2015, 76:192-202. DOI: 10.1016/j.ejps.2015.04.023
Janočková J., Plšíková J., Koval‘ J., Jendželovský R., Mikeš J., Kašpárková J., Brabec V., Hamuľaková S., Fedoročko P., Kožurková M. Tacrine derivatives as dual topoisomerase I and II catalytic inhibitors. Bioorganic Chemistry, 2015, 59:168-176. DOI: 10.1016/j.bioorg.2015.03.002
Nagel R, Bernholz C, Vranova E, Kosuth J, Bergau N, Ludwig S, Wessjohann L, Gershenzon J, Tissier A, Schmidt A. Arabidopsis thaliana isoprenyl diphosphate synthases produce the C-25 intermediate geranylfarnesyl diphosphate. Plant Journal, 2015, 84(5), 847-859, DOI: 10.1111/tpj.13064
2014
Matiašová, A., Ševc, J., Mikeš, J., Jendželovský, R., Daxnerová, Z., Fedoročko, P. Flow cytometric determination of 5-bromo-2 ́-deoxyuridine pharmacokinetics in blood serum after intraperitoneal administration to rats and mice. Histochemistry and Cell Biology, 2014, 142: 703-712. DOI: 10.1007/s00418-014-1253-7
Ševc, J., Matiašová, A., Kútna, V., Daxnerová, Z. Evidence that the central canal lining of the spinal cord contributes to oligodendrogenesis during postnatal development and adulthood in intact rats, In: Journal of Comparative Neurology, 2014, 522(14):3194-207. DOI: 10.1002/cne.23590
Kútna, V., Ševc, J., Gombalová, Z., Matiašová, A., Daxnerová Z. Enigmatic cerebrospinal fluid-contacting neurons arise even after the termination of neurogenesis in the rat spinal cord during embryonic development and retain their immature-like characteristics until adulthood. Acta Histochemica, 2014, 116(1): 278-285. DOI: 10.1016/j.acthis.2013.08.004
Kisková T., Jendželovský R., Rentsen E., Maier-Salamon A., Kokošová N., Papčová Z., Mikeš J., Orendáš P., Bojková B., Kubatka P., Svoboda M., Kajo K., Fedoročko P., Jäger W., Ekmekcioglu C., Kassayová M., Thalhammer T. Resveratrol enhances the chemopreventive effect of celecoxib in chemically induced breast cancer in rats. European Journal of Cancer Prevention, 2014, 23:506-13. DOI: 10.1097/CEJ.0000000000000083
Jendželovská Z., Jendželovský R., Hiľovská L., Kovaľ J., Mikeš J., Fedoročko P. Single pre-treatment with hypericin, a St. John′swort secondary metabolite, attenuates cisplatin- and mitoxantrone-induced cell death in A2780, A2780cis and HL-60 cells. Toxicology in Vitro, 2014, 28:1259-1273. DOI: 10.1016/j.tiv.2014.06.011
2013
Ševc, J., Goldberg, D., van Gorp, S., Leerink, M., Juhas, S., Juhasova, J., Marsala, S., Hruska-Plochan, M., Hefferan, M.P., Motlik, J., Rypacek, F., Machova, L., Kakinohana, O., Santucci, C., Johe, K., Lukacova, N., Yamada, K., Bui, J.D., Marsala, M. Effective long-term immunosuppression in rats by subcutaneously implanted sustained-release tacrolimus pellet: Effect on spinally grafted human neural precursor survival. Experimental Neurology, 2013, 248:85-99. DOI: 10.1016/j.expneurol.2013.05.017
Kosuth J, Hrehorova D, Jaskolski M, Cellarova E. Stress-induced expression and structure of the putative gene hyp-1 for hypericin biosynthesis. Plant Cell Tissue and Ogan Culture, 2013, 114(2), 207-216, DOI: 10.1007/s11240-013-0316-0
Mikeš J., Kovaľ J., Jendželovský R., Mikešová L., Šinkorová Z., Fedoročko P. Procedure for improved cleaning of FACSAria cuvette flow cell. Cytometry PART A, Communication to the editor, 2013, 83A(6):523-527. DOI: 10.1002/cyto.a.22293
Mikešová L., Mikeš J., Valeková B., Gyurászová K., Čulka Ľ., Vargová J., Kovaľ J., Fedoročko P. Conjunction of glutathione level, NAD(P)H/FAD redox potential and hypericin content as a potential factor affecting colon cancer cells-resistance to photodynamic therapy with hypericin. Photodiagnosis and Photodynamic Therapy, 2013, 10:470-83. DOI: 10.1016/j.pdpdt.2013.04.003
2012
Šemeláková M., Mikeš J., Jendželovský R., Fedoročko P. The pro-apoptotic and anti-invasive effects of hypericin-mediated photodynamic therapy are enhanced by hyperforin or aristoforin in HT-29 colon adenocarcinoma cells. Journal of Photochemistry and Photobiology B: Biology, 2012, 117:115-125. DOI: 10.1016/j.jphotobiol.2012.09.003
Plšíková J., Janovec L., Kovaľ J., Ungvarský J., Mikeš J., Jendželovský R., Fedoročko P., Imrich J., Kristián P., Kašpárková J., Brabec V., Kožurková M. 3,6-Bis(3-alkylguanidino)acridines as DNA-intercalating antitumor agents. European Journal of Medicinal Chemistry, 2012, 57:283-295. DOI: 10.1016/j.ejmech.2012.09.020
Jendželovský R., Kovaľ J., Mikeš J., Papčová Z., Plšíková J., Fedoročko P. Inhibition of GSK-3β reverses the pro-apoptotic effect of proadifen (SKF-525A) in HT-29 colon adenocarcinoma cells. Toxicology in Vitro, 2012, 26:775-782. DOI: 10.1016/j.tiv.2012.05.014
Bačkorová M., Jendželovský R., Kello M., Bačkor M., Mikeš J., Fedoročko P. Lichen secondary metabolites are responsible for induction of apoptosis in HT-29 and A2780 human cancer cell lines. Toxicology in Vitro, 2012, 26:462-468. DOI: 10.1016/j.tiv.2012.01.017
2011
Mikeš J., Hýžďalová M., Kočí L., Jendželovský R., Kovaľ J., Vaculová A., Hofmanová J., Kozubík A., Fedoročko P. Lower sensitivity of FHC fetal colon epithelial cells to photodynamic therapy compared to HT-29 colon danocarcinoma cells despite higher itracellular accumulation of hypericin. Photochemical & Photobiological Sciences, 2011, 10:626-632. DOI: 10.1039/c0pp00359j
Bačkorová M., Bačkor M., Mikeš J., Jendželovský R., Fedoročko P. Variable responses of different human cancer cells to lichen compounds parietin, atranorin, usnic acid and gyrophoric acid. Toxicology in Vitro, 2011,25(1):37-44. DOI: 10.1016/j.tiv.2010.09.004
Ševc J, Daxnerová Z, Haňová V, Koval‘ J. Novel observations on the origin of ependymal cells in the ventricular zone of the rat spinal cord. Acta Histochem., 2011, 113:156-62. DOI: 10.1016/j.acthis.2009.09.007
Kosuth J, Smelcerovic A, Borsch T, Zuehlke S, Karppinen K, Spiteller M, Hohtola A, Cellarova E. The hyp-1 gene is not a limiting factor for hypericin biosynthesis in the genus Hypericum. Functional Plant Biology, 2011, 38(1):35-43, DOI: 10.1071/FP10144
2010
Kello M., Mikeš J., Jendželovský R., Kovaľ J., Fedoročko P. PUFAs enhance oxidative stress and apoptosis in tumour cells exposed to hypericin-mediated PDT. Photochemical & Photobiological Sciences, 2010, 9:1244-1251. DOI: 10.1039/c0pp00085j
Kovaľ J., Mikeš J., Jendželovský R., Kello M., Solár P., Fedoročko P. Degradation of HER2 receptor through hypericin-mediated photodynamic therapy. Photochemistry and Photobiology, 2010, 86(1):200-205. DOI: 10.1111/j.1751-1097.2009.00639.x
